<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04403997</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-16T11:00:37+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Latest development of α emitter imaging and quantification on a large Field Of View for Targeted Alpha Therapy applications</title>
            <author role="aut">
              <persName>
                <forename type="first">Arthur</forename>
                <surname>Bongrand</surname>
              </persName>
              <email type="md5">40a247ae017700cdfc6d1e664cd79294</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="string">arthur-bongrand</idno>
              <idno type="idhal" notation="numeric">753706</idno>
              <idno type="halauthorid" notation="string">1321539-753706</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7074-9672</idno>
              <affiliation ref="#struct-1088589"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Samuel</forename>
                <surname>Duval</surname>
              </persName>
              <idno type="halauthorid">558712-0</idno>
              <affiliation ref="#struct-1089149"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jérôme</forename>
                <surname>Donnard</surname>
              </persName>
              <idno type="halauthorid">1459329-0</idno>
              <affiliation ref="#struct-1089149"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Julie</forename>
                <surname>Champion</surname>
              </persName>
              <email type="md5">bf5fa17ab43a2dbbc54ed2d140e37d98</email>
              <email type="domain">subatech.in2p3.fr</email>
              <idno type="idhal" notation="string">juliechampion</idno>
              <idno type="idhal" notation="numeric">177388</idno>
              <idno type="halauthorid" notation="string">46201-177388</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6683-3334</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.co.uk/citations?user=pwk2w3IAAAAJ&amp;hl=en</idno>
              <idno type="IDREF">https://www.idref.fr/14932023X</idno>
              <idno type="VIAF">https://viaf.org/viaf/173814081</idno>
              <affiliation ref="#struct-1088589"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Arthur</forename>
                <surname>BONGRAND</surname>
              </persName>
              <email type="md5">1b7a4c0ca74b2806f9d3925aa4a03ac9</email>
              <email type="domain">subatech.in2p3.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2024-01-18 17:55:30</date>
              <date type="whenModified">2026-02-07 05:27:10</date>
              <date type="whenReleased">2024-01-22 11:42:14</date>
              <date type="whenProduced">2023-07-23</date>
              <date type="whenEndEmbargoed">2024-01-18</date>
              <ref type="file" target="https://hal.science/hal-04403997v1/document">
                <date notBefore="2024-01-18"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-04403997v1/file/5_TherapeuticsII_175_BONGRAND_Arthur_vHAL.pdf" id="file-4403997-3830758">
                <date notBefore="2024-01-18"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1165326">
                <persName>
                  <forename>Arthur</forename>
                  <surname>BONGRAND</surname>
                </persName>
                <email type="md5">1b7a4c0ca74b2806f9d3925aa4a03ac9</email>
                <email type="domain">subatech.in2p3.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04403997</idno>
            <idno type="halUri">https://hal.science/hal-04403997</idno>
            <idno type="halBibtex">bongrand:hal-04403997</idno>
            <idno type="halRefHtml">&lt;i&gt;11th International Conference on Isotopes (11ICI)&lt;/i&gt;, Sylvia Fedoruk Canadian Centre for Nuclear Innovation (the Fedoruk Centre); University of Saskatchewan; Tourism Saskatoon, Jul 2023, Saskatoon, Saskatchewan, Canada</idno>
            <idno type="halRef">11th International Conference on Isotopes (11ICI), Sylvia Fedoruk Canadian Centre for Nuclear Innovation (the Fedoruk Centre); University of Saskatchewan; Tourism Saskatoon, Jul 2023, Saskatoon, Saskatchewan, Canada</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-4403997-3830758"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="IN2P3">Institut National de Physique Nucléaire et de Physique des Particules</idno>
            <idno type="stamp" n="MINES-NANTES">Ecole des Mines de Nantes</idno>
            <idno type="stamp" n="SUBATECH" corresp="MINES-NANTES">Laboratoire SUBATECH Nantes</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="SUB" corresp="MINES-NANTES">Département physique subatomique et technologies associées</idno>
            <idno type="stamp" n="IMTA_SUBATECH">IMT Atlantique - Département physiques subatomiques et technologies</idno>
            <idno type="stamp" n="IMT-ATLANTIQUE" corresp="INSTITUT-MINES-TELECOM">IMT-ATLANTIQUE</idno>
            <idno type="stamp" n="SUBATECH-PRISMA">Prisma (SUBATECH)</idno>
            <idno type="stamp" n="INSTITUTS-TELECOM">composantes instituts telecom </idno>
            <idno type="stamp" n="NANTES-UNIVERSITE">Nantes Université</idno>
            <idno type="stamp" n="NANTES-UNIV">Nantes Université</idno>
            <idno type="stamp" n="INSTITUT-MINES-TELECOM">Institut Mines Telecom</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="invited" n="0">No</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
            <note type="proceedings" n="0">No</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Latest development of α emitter imaging and quantification on a large Field Of View for Targeted Alpha Therapy applications</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Arthur</forename>
                    <surname>Bongrand</surname>
                  </persName>
                  <email type="md5">40a247ae017700cdfc6d1e664cd79294</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="string">arthur-bongrand</idno>
                  <idno type="idhal" notation="numeric">753706</idno>
                  <idno type="halauthorid" notation="string">1321539-753706</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7074-9672</idno>
                  <affiliation ref="#struct-1088589"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Samuel</forename>
                    <surname>Duval</surname>
                  </persName>
                  <idno type="halauthorid">558712-0</idno>
                  <affiliation ref="#struct-1089149"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jérôme</forename>
                    <surname>Donnard</surname>
                  </persName>
                  <idno type="halauthorid">1459329-0</idno>
                  <affiliation ref="#struct-1089149"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Julie</forename>
                    <surname>Champion</surname>
                  </persName>
                  <email type="md5">bf5fa17ab43a2dbbc54ed2d140e37d98</email>
                  <email type="domain">subatech.in2p3.fr</email>
                  <idno type="idhal" notation="string">juliechampion</idno>
                  <idno type="idhal" notation="numeric">177388</idno>
                  <idno type="halauthorid" notation="string">46201-177388</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6683-3334</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.co.uk/citations?user=pwk2w3IAAAAJ&amp;hl=en</idno>
                  <idno type="IDREF">https://www.idref.fr/14932023X</idno>
                  <idno type="VIAF">https://viaf.org/viaf/173814081</idno>
                  <affiliation ref="#struct-1088589"/>
                </author>
              </analytic>
              <monogr>
                <meeting>
                  <title>11th International Conference on Isotopes (11ICI)</title>
                  <date type="start">2023-07-23</date>
                  <date type="end">2023-07-27</date>
                  <settlement>Saskatoon, Saskatchewan</settlement>
                  <country key="CA">Canada</country>
                </meeting>
                <respStmt>
                  <resp>conferenceOrganizer</resp>
                  <name>Sylvia Fedoruk Canadian Centre for Nuclear Innovation (the Fedoruk Centre)</name>
                  <name>University of Saskatchewan</name>
                  <name>Tourism Saskatoon</name>
                </respStmt>
                <imprint/>
              </monogr>
              <ref type="publisher">https://www.11ici.org/</ref>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Autoradiography</term>
                <term xml:lang="en">Autoradiography imager</term>
                <term xml:lang="en">Autoradiography quantitative</term>
                <term xml:lang="en">Autoradiographie alpha</term>
              </keywords>
              <classCode scheme="halDomain" n="phys">Physics [physics]</classCode>
              <classCode scheme="halDomain" n="phys.phys.phys-ins-det">Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]</classCode>
              <classCode scheme="halDomain" n="phys.phys.phys-med-ph">Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph]</classCode>
              <classCode scheme="halTypology" n="COMM">Conference papers</classCode>
              <classCode scheme="halOldTypology" n="COMM">Conference papers</classCode>
              <classCode scheme="halTreeTypology" n="COMM">Conference papers</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>IntroductionAlthough very promising, the development of Targeted Alpha Therapy (TAT) requires the use of accurate techniques that can identify and quantify individual radionuclides in different matrices. However, currently, characterization of the nature and spatial distribution of radionuclides in a sample is time consuming and fastidious. Indeed, it necessarily requires the use of two distinct analytical techniques and detectors of different nature. Moreover, the resolutions of the two methods are often different from each other because they also depend on the nature of the detector used, which makes it difficult to integrate and interpret these two types of measurements together. To overcome these limitations, as well as to simplify and to accelerate the measurement process, it is now possible to use a digital autoradiograph capable of combining the measurement of the spatial distribution with the ability to separate and quantify each radionuclide.Description of the Work or ProjectFor this purpose, a set of temporal and energy spectrometry techniques had to be specifically developed. On the one hand, the use of instruments capable of recording the location of each decay product allows to measure the evolution of the activity of the sample and thus, to deduce the contributions of several radionuclides. On the other hand, the development of an innovative method of autoradiography spectroscopy in particle energy also allows to separate them by measuring their initial energy. Even if the efficiency of energy spectrum reconstruction is low (&lt;5%) compared to the efficiency of a simple autoradiograph (50%), this novel measurement approach offers the opportunity to select areas on an autoradiograph to perform an energy spectrum analysis within that area. Although if the samples usable on this type of instrument must generally be of solid nature, recent developments show that it is possible to use fluid samples (liquid or gas) with a cell system. Eventually, the proposed measurement system could allow dynamic imaging of radionuclides of interest.ConclusionsFrom an application point of view, this opens up possibilities for theragnostic applications that typically use two radionuclides. Further upstream, it can optimize the production and distribution challenge of α radionuclides by allowing the identification and characterization of individual radionuclides in radionuclide chains such as 225Ac. Moreover, the measurement system and the associated method could strongly contribute to facilitate research on the biodistribution of α radionuclides.ReferencesLefeuvre, H., Donnard, J., Descostes, M., Billon, S., Duval, S., Oger, T., Toubon, H. &amp; Sardini, P. (2022). Spectroscopic Autoradiography of Alpha Particles Using a Parallel Ionization Multiplier Gaseous Detector. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. https://doi.org/10.1016/j.nima.2022.166807</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1088589" status="VALID">
          <idno type="IdRef">221427864</idno>
          <idno type="RNSR">199612295L</idno>
          <idno type="ROR">https://ror.org/01kxesq83</idno>
          <orgName>Laboratoire de physique subatomique et des technologies associées</orgName>
          <orgName type="acronym">SUBATECH</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>IMT Atlantique - Campus de Nantes - La Chantrerie - 4, rue Alfred Kastler - CS 20722 - 44307 NANTES Cedex 3</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-subatech.in2p3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300046" type="direct"/>
            <relation name="UMR6457" active="#struct-441569" type="direct"/>
            <relation active="#struct-481355" type="direct"/>
            <relation active="#struct-302102" type="indirect"/>
            <relation active="#struct-1088543" type="direct"/>
            <relation active="#struct-1083400" type="indirect"/>
            <relation active="#struct-1083366" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1089149" status="VALID">
          <orgName>Ai4r – Atlantic Instruments for Research</orgName>
          <orgName type="acronym">Ai4r SAS</orgName>
          <date type="start">2012-06-25</date>
          <desc>
            <address>
              <addrLine>2 rue Alfred Kastler, CS 70727, 44 307 Nantes Cedex 3</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ai4r.com</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300046" status="VALID">
          <idno type="IdRef">028227875</idno>
          <idno type="ISNI">0000000106643574</idno>
          <idno type="ROR">https://ror.org/03fd77x13</idno>
          <orgName>Institut National de Physique Nucléaire et de Physique des Particules du CNRS</orgName>
          <orgName type="acronym">IN2P3</orgName>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://in2p3.cnrs.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-481355" status="VALID">
          <idno type="IdRef">202743233</idno>
          <idno type="ROR">https://ror.org/030hj3061</idno>
          <orgName>IMT Atlantique</orgName>
          <orgName type="acronym">IMT Atlantique</orgName>
          <date type="start">2017-01-01</date>
          <desc>
            <address>
              <addrLine>Campus Brest : Technopôle Brest-Iroise CS 8381829238 BREST Cedex 3 -Campus Nantes : 4, rue Alfred Kastler- La chantrerie 44300 NANTES -Campus Rennes :  2 Rue de la Châtaigneraie, 35510 CESSON SEVIGNE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.imt-atlantique.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-302102" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-302102" status="VALID">
          <idno type="IdRef">192427156</idno>
          <idno type="ISNI">000000012202567X</idno>
          <idno type="ROR">https://ror.org/025vp2923</idno>
          <idno type="Wikidata">Q27962533</idno>
          <orgName>Institut Mines-Télécom [Paris]</orgName>
          <orgName type="acronym">IMT</orgName>
          <date type="start">2012-03-01</date>
          <desc>
            <address>
              <addrLine>19 Place Marguerite Perey, 91120 Palaiseau</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.imt.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1088543" status="VALID">
          <orgName>Nantes université - UFR des Sciences et des Techniques</orgName>
          <orgName type="acronym">Nantes univ -  UFR ST</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>2, rue de la Houssinière - BP 92208 - 44322 Nantes cedex 3</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sciences-techniques.univ-nantes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1083400" type="direct"/>
            <relation active="#struct-1083366" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1083400" status="VALID">
          <orgName>Nantes Université - pôle Sciences et technologie</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://nouvelleuniversite.univ-nantes.fr/les-poles</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1083366" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1083366" status="VALID">
          <idno type="IdRef">258086599</idno>
          <idno type="ROR">https://ror.org/03gnr7b55</idno>
          <orgName>Nantes Université</orgName>
          <orgName type="acronym">Nantes Univ</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>