Generalization of endothelial modelling of TSPO PET imaging: Considerations on tracer affinities
Résumé
The 18 kDa translocator protein (TSPO) is a marker of microglia activation and the main target of positron emission tomography (PET) ligands for neuroinflammation. Previous works showed that accounting for TSPO endothelial binding improves PET quantification for [
Mots clés
- neuroinflammation
- microglia
- endothelium
- clustering
- reference region
- kinetic modelling
- [ 11 C]PBR28
- [ 18 F]DPA714
- [ 11 C]-R-PK11195
- Translocator protein
- Translocator protein [ 11 C]-R-PK11195 [ 18 F]DPA714 [ 11 C]PBR28 kinetic modelling neuroinflammation microglia endothelium clustering reference region
Domaines
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