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Poster De Conférence Année : 2019

The HDX approach to evidence the stepwise character of controlled enantioselective reduction of copper II complexes with polar amino acids

Résumé

For LPgly/LPro/L/DAA/CuII quaternary complexes under resonant excitation (CID mode), a significant enantioselective CuII reduction occurs when the side chain of the AA partner complex is nonpolar. Here, HDX approach was applied to investigate the behavior of these complexes by variation of activation time. The enantioselective reduction of complexes where all mobile protons are deuterated mainly results in the unexpected losses of (CO2+C6H5CD°ND2) radical rather than (CO2+C6H5CH°ND2) by an unusual stepwise mechanism. In the case of AA=Glu, a particular conformation of the side chain can be reached to promote a reversible D transfer preventing the chiral effect.

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Dates et versions

hal-04401368 , version 1 (17-01-2024)
hal-04401368 , version 2 (18-01-2024)

Identifiants

  • HAL Id : hal-04401368 , version 2

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Ekaterina Darii, Annelaure Damont, Denis Lesage, Sandra Alves, Alain Perret, et al.. The HDX approach to evidence the stepwise character of controlled enantioselective reduction of copper II complexes with polar amino acids. 67th ASMS Conference on Mass Spectrometry and Allied Topics, Jun 2019, Atlanta, United States. . ⟨hal-04401368v2⟩
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