In vivo, cells are surrounded by an extracellular matrix (ECM). Signals from the ECM such as biochemical or biophysical cues regulate cell behavior significantly. Although, 3D cell cultures offer biologically superior structures, there is still a lack in the transmission of dynamic mechanical signals that exist in the microenvironment of cells in vivo. The aim of this work is to develop a 4D microporous and electroactive scaffold as an innovative cell culture platform that enables the in situ electromechanical stimulation of cells and monitoring of the cell behavior. For this purpose, a 3D microporous scaffold is obtained from the polymerization of a high internal phase emulsion template. This so called polyHIPE is characterized by a high interconnectivity and a suitable porosity for a rapid cell colonization. In a further step the polyHIPE-scaffold is functionalized with a conducting polymer, the poly(3,4-ethylenedioxthiophene) (PEDOT). The functionalization leads to a 4D electroactive polyHIPE-PEDOT scaffold with stimuli-responsive properties such as changes in shape, morphology and pore size under external stimulation. Our results show that the stimulation process is reversible, stable and generates volume variations up to 10% on the scaffolds. Furthermore, the polyHIPE-PEDOT scaffolds support cell adhesion, spreading, migration and the cell viability is not affected by 5h of electromechanical stimulation. Main objective Participation to this conference was partially supported by I-MAT federation (FD 4122), INEX-CY Initiative (3DSTIM-2019-054-C01A0) and RESPORE IDF (4D E-BIOCELL).