Article Dans Une Revue Catalysts Année : 2018

Palladium-Catalyzed Regioselective Alkoxylation via C-H Bond Activation in the Dihydrobenzo[c]acridine Series

Résumé

5,6-Dihydrobenzo[c]acridine belongs to the large aza-polycyclic compound family. Such molecules are not fully planar due to the presence of a partially hydrogenated ring. This paper describes the first Pd-catalyzed alkoxylation via C-H bond activation of variously substituted 5,6-dihydrobenzo[c]acridines. We determined suitable conditions to promote the selective formation of C-O bonds using 10% Pd(OAc)2, PhI(OAc)2 (2 eq.) and MeOH as the best combination of oxidant and solvent, respectively. Under these conditions, 5,6-dihydrobenzo[c]acridines bearing substituents at both rings A and D were successfully functionalized, giving access to polysubstitutited acridine motifs

Fichier principal
Vignette du fichier
catalysts-08-00139.pdf (3.01 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Licence

Dates et versions

hal-03119329 , version 1 (07-06-2023)

Licence

Identifiants

Citer

Benjamin Large, Flavien Bourdreux, Aurélie Damond, Anne Gaucher, Damien Prim. Palladium-Catalyzed Regioselective Alkoxylation via C-H Bond Activation in the Dihydrobenzo[c]acridine Series. Catalysts, 2018, 8 (4), pp.139. ⟨10.3390/catal8040139⟩. ⟨hal-03119329⟩
152 Consultations
138 Téléchargements

Altmetric

Partager

  • More