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Article Dans Une Revue British Journal of Haematology Année : 2018

Clinical value of automated fibrin generation markers in patients with septic shock: a SepsiCoag ancillary study

Eva Cochery-Nouvellon
  • Fonction : Auteur
Samir Jaber
  • Fonction : Auteur
Jacques Albanese
  • Fonction : Auteur
Jean‐michel Constantin
  • Fonction : Auteur
Jean‐christophe Orban
  • Fonction : Auteur
Jérôme Morel
  • Fonction : Auteur
Marc Leone
  • Fonction : Auteur
Pauline Deras
  • Fonction : Auteur
Loubna Elotmani
  • Fonction : Auteur
Géraldine Lavigne-Lissalde
  • Fonction : Auteur
Jean‐yves Lefrant
  • Fonction : Auteur

Résumé

Summary An ancillary analysis to the SepsiCoag multicentric prospective observational study on patients entering an intensive care unit with septic shock evaluated the prognostic potential of fibrin generation markers ( FGM s) tested at inclusion in the study, on survival at day 30. After centralization of samples, three automated FGM s were compared: D‐dimers (DDi), fibrin/fibrinogen degradation products ( FDP ) and fibrin monomers ( FM ). FM was the single FGM that was significantly higher in non‐surviving patients, area under the receiver‐operator characteristic curve (AUC ROC ): 0·617, P < 0·0001. Significantly higher International Society on Thrombosis and Haemostasis Disseminated Intravascular Coagulation ( ISTH DIC ) scores were calculated in non‐survivors using each of the three FGM s. A dose‐effect relationship was observed between ISTH DIC scores and non‐survival, with highest significance obtained using FM as the FGM . An overt DIC diagnosis using the ISTH DIC score calculated using FM was a predictor of non‐survival at day 30, independently from overt DIC diagnosis based on scores calculated using FDP or DDi . The AUC ROC values testing the ability of the ISTH DIC score to predict non‐survival were 0·650, 0·624 and 0·602 using FM , DDi and FDP , respectively, as the FGM . In patients with septic shock, among the commercially‐available automated assays, automated FM is the FGM best related with late prognosis.

Dates et versions

hal-04394203 , version 1 (15-01-2024)

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Citer

Jean‐christophe Gris, Eva Cochery-Nouvellon, Sylvie Bouvier, Samir Jaber, Jacques Albanese, et al.. Clinical value of automated fibrin generation markers in patients with septic shock: a SepsiCoag ancillary study. British Journal of Haematology, 2018, 183 (4), pp.636-647. ⟨10.1111/bjh.15576⟩. ⟨hal-04394203⟩
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