The purpose of this study was to compare composite indices of femoral neck strength ((compression strength index [CSI], bending strength index [BSI], and impact strength index [ISI]) in inactive middle-aged men (n = 20) and middle-aged former football players (n = 15). 35 middle-aged men participated in this study. Body composition and bone variables were evaluated by dual-energy X-ray absorptiometry. Composite indices of femoral neck strength (CSI, BSI, and ISI) were calculated. Handgrip strength, vertical jump, maximum power of the lower limbs (watts), horizontal jump, maximal half-squat strength, maximal bench-press strength, sprint performance (10 meters), and maximum oxygen consumption (VO2 max, ml/min/kg) were evaluated using validated tests. CSI, BSI, and ISI were significantly higher in football players compared to inactive men. Vertical jump, horizontal jump, maximal half-squat strength, VO2 max and sprint performance were significantly different between the 2 groups. CSI, BSI, and ISI remained significantly higher in football players compared to inactive men after adjusting for physical activity level. The current study suggests that former football practice is associated with higher composite indices of femoral neck strength in middle-aged men.