3D technology and antibacterial post-treatments: the process for the future manufacturing of bone substitutes?
Résumé
Various 3D methods have been more and more used for the manufacturing of macroporous
bioceramics for bone substitution applications. It is then legitimate to question the relevance
of these methods regarding cellular behavior and recolonization of the ceramic parts in
healthy or pathogenic biological conditions as nosocomial diseases. A first part of this talk
will present the results of Chamary's PhD work devoted to the comparison of macroporous
calcium phosphate architectures manufactured by a series of techniques: the replica
technique from a polymer ball skeleton impregnated with ceramic slurry, the ice templating
from ceramic slurry and the additive SLA method with regard to bone recolonization. These
methods lead to very different porosity structures in terms of size and shape which has a
real impact on cell migration inside the bone substitute. The second part of the talk will
present three different routes developed in our laboratories in order to implement
antibacterial properties in bone substitutes: ceramic surface modification by laser
treatment, antiviral phage deposition on ceramic powder and substrate and synthesis of
antimicrobial peptides (AMPs) by recombinant technology and grafting on biomaterials.