5‐ endo‐dig Cyclization of O‐Propargyl Mandelic Acid Amides towards 2,5‐Dihydrofurans
Résumé
5‐ endo‐dig cyclization of O‐propargyloxyamides, obtained through a Passerini reaction mediated by boric acid and subsequent propargylation, affords 2,5‐dihydrofurans in the presence of tert ‐butylate. The mechanism of the reaction was studied by using DFT calculations and the results were compared with the behavior of analogous N‐propargylamide derivatives.
Domaines
Chimie
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