T he UniL ectin portal (ht tps://unilectin.unige.c h/) was designed in 2019 with the goal of centralising curated and predicted data on carboh y dratebinding proteins known as lectins. UniLectin is also intended as a support for the study of lectomes (full lectin set) of organisms or tissues. The present update describes the inclusion of several new modules and details the latest (ht tps://unilectin.unige.c h/humanL ectome/), co v ering our knowledge of the human lectome and comprising 215 une v enly characterised lectins, particularly in terms of str uct ural information. Each HumanLectome entry is protein-centric and compiles evidence of carbohydrate recognition domain(s), specificity, 3D-str uct ure, tissue-based expression and related genomic data. Other recent improvements regarding interoperability and accessibility are outlined.