We show that the continuous L p-cohomology of locally compact second countable groups is a quasi-isometric invariant. As an application, we prove partial results supporting a positive answer to a question asked by M. Gromov, suggesting a classical behaviour of continuous L p-cohomology of simple real Lie groups. In addition to quasi-isometric invariance, the ingredients are a spectral sequence argument and Pansu's vanishing results for real hyperbolic spaces. In the best adapted cases of simple Lie groups, we obtain nearly half of the relevant vanishings.