Since early 2020, the Covid-19 (CoronaVIrus Disease-19) pandemic has affected our world in multiple ways. What we know and how we know it has shifted on a global scale. How we move throughout the world has been restricted and locked down. How we see one another has changed the cultural narrative in numerous countries throughout the world. As we seek to rid ourselves of the novel coronavirus infecting our everyday, three significant paradigm shifts have mutated our realities and imaginaries in which we dwell. With millions dead or sickened by the evolving Covid-19 virus (According to the World Health Organization, “Globally, as of 8:32 pm CET, 9 February 2022, there have been 399,600,607 confirmed cases of COVID-19, including 5,757,562 deaths, reported to WHO. As of 7 February 2022, a total of 10,095,615,243 vaccine doses have been administered.” Source: https://covid19.who.int; Accessed Feb 9, 2022.), we are a different world now than we were. As guest editors for this Special Issue, (In)Visible Mutations of the (Mis)Information Imaginary: Knowledge, Movement, and Cultural Discourse in the Wake of Covid-19, we pay tribute to the millions affected by these changes by offering this collection of scholarship as a critical path forward. We examine three primary areas in which life, law, and legality have mutated with results that demand our immediate attention. The first section of contributing articles, Knowledge, engages with the dissemination of knowledge and (mis)information as either fact or fiction in lexicons and media outlets throughout the world. The second section, Movement, focuses on aspects of motion and its restriction in terms of bodies, legislation, access, and the threat of viral contamination across borders and within communities. The third section, Cultural Discourse, considers the (in)visibility of viral spread ranging from masks that cover the face to the separation of bodies through social distancing to the politicization of religion and vaccination. What once were normative cultural positionalities of space and politics have been volatized by institutionalized risk reduction and the confrontation of the unknown in the tenuous unforeseeable realm we now globally inhabit: L’idée se fait jour qu’il s’agit au moins autant d’une syndémie que d’une pandémie. Alors que la pandémie est une épidémie qui touche une partie importante de la population mondiale, une syndémie caractérise un entrelacement de maladie, de facteurs biologiques et environnementaux qui, par leur synergie, aggravent les conséquences de ces maladies sur la population. Ost F (De quoi le Covid est-il le nom ? Académie Royale de Belgique, Bruxelles, 2021, p. 6). We hope that this Special Issue helps to contribute as a vital source of critical engagement with the effects of the new pandemic lexicon and re-emerging, yet irrevocably mutated public and private spaces and relationships to each another.