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Pré-Publication, Document De Travail Année : 2023

Synthesis of peptides by reactive extrusion. Application to the continuous and solventless preparation of aspartame

Résumé

The solventless synthesis of peptides from unactivated amino acids was performed in a twin-screw extruder. The general method was applied to the preparation of dipeptides and tripeptides. Aspartame, a synthetic dipeptide, was also prepared in a continuous mode on large scale.

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Chimie
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Dates et versions

hal-04361336 , version 1 (22-12-2023)

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Tharwat Mohy El-Dine, Matthieu Lavayssiere, Hélène Adihou, Gilles Subra, Thomas- Xavier Métro, et al.. Synthesis of peptides by reactive extrusion. Application to the continuous and solventless preparation of aspartame. 2023. ⟨hal-04361336⟩
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