<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04360544</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-08T23:12:18+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">PNIPAM-stabilized cubosomes as fusogenic delivery nanovectors for anticancer applications</title>
            <author role="aut">
              <persName>
                <forename type="first">Arianna</forename>
                <surname>Balestri</surname>
              </persName>
              <idno type="halauthorid">2056379-0</idno>
              <affiliation ref="#struct-192129"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laure</forename>
                <surname>Gibot</surname>
              </persName>
              <email type="md5">d4223d61c7e9fb9fe54eac35f16160b2</email>
              <email type="domain">cnrs.fr</email>
              <idno type="idhal" notation="string">laure-gibot</idno>
              <idno type="idhal" notation="numeric">184501</idno>
              <idno type="halauthorid" notation="string">10563-184501</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7255-4123</idno>
              <idno type="IDREF">https://www.idref.fr/117481483</idno>
              <affiliation ref="#struct-756"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Heinz</forename>
                <surname>Amenitisch</surname>
              </persName>
              <idno type="halauthorid">2997594-0</idno>
              <affiliation ref="#struct-65509"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lorenzo</forename>
                <surname>Cervelli</surname>
              </persName>
              <idno type="halauthorid">2997595-0</idno>
              <affiliation ref="#struct-192129"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Costanza</forename>
                <surname>Montis</surname>
              </persName>
              <idno type="idhal" notation="numeric">795497</idno>
              <idno type="halauthorid" notation="string">1609570-795497</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6960-3772</idno>
              <affiliation ref="#struct-192129"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Barbara</forename>
                <surname>Lonetti</surname>
              </persName>
              <email type="md5">00ff46e851e284f70869fe3de6cf8cd7</email>
              <email type="domain">chimie.ups-tlse.fr</email>
              <idno type="idhal" notation="string">barbara-lonetti</idno>
              <idno type="idhal" notation="numeric">1251898</idno>
              <idno type="halauthorid" notation="string">126583-1251898</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4291-6861</idno>
              <idno type="IDREF">https://www.idref.fr/18584796X</idno>
              <idno type="VIAF">https://viaf.org/viaf/316670420</idno>
              <affiliation ref="#struct-756"/>
              <affiliation ref="#struct-1178841"/>
              <affiliation ref="#struct-1178837"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Debora</forename>
                <surname>Berti</surname>
              </persName>
              <idno type="halauthorid">1609569-0</idno>
              <affiliation ref="#struct-192129"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Barbara</forename>
                <surname>Lonetti</surname>
              </persName>
              <email type="md5">1206a0c776f066be4e19687f26aeb73d</email>
              <email type="domain">cnrs.fr</email>
            </editor>
            <funder ref="#projanr-50804"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2023-12-21 19:57:01</date>
              <date type="whenModified">2025-10-24 03:18:13</date>
              <date type="whenReleased">2023-12-21 19:57:01</date>
              <date type="whenProduced">2023-11</date>
              <ref type="externalLink" target="https://doi.org/10.1016/j.colsurfb.2023.113532"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="436609">
                <persName>
                  <forename>Barbara</forename>
                  <surname>Lonetti</surname>
                </persName>
                <email type="md5">1206a0c776f066be4e19687f26aeb73d</email>
                <email type="domain">cnrs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04360544</idno>
            <idno type="halUri">https://hal.science/hal-04360544</idno>
            <idno type="halBibtex">balestri:hal-04360544</idno>
            <idno type="halRefHtml">&lt;i&gt;Colloids and Surfaces B: Biointerfaces&lt;/i&gt;, 2023, 231, pp.113532. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.colsurfb.2023.113532"&gt;&amp;#x27E8;10.1016/j.colsurfb.2023.113532&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Colloids and Surfaces B: Biointerfaces, 2023, 231, pp.113532. &amp;#x27E8;10.1016/j.colsurfb.2023.113532&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="TOULOUSE-INP">Toulouse - INP</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="SOFTMAT">Laboratoire Chimie des colloïdes, polymères &amp; assemblages complexes</idno>
            <idno type="stamp" n="ICT-CHIMIE">ICT-CHIMIE </idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">PNIPAM-stabilized cubosomes as fusogenic delivery nanovectors for anticancer applications</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Arianna</forename>
                    <surname>Balestri</surname>
                  </persName>
                  <idno type="halauthorid">2056379-0</idno>
                  <affiliation ref="#struct-192129"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laure</forename>
                    <surname>Gibot</surname>
                  </persName>
                  <email type="md5">d4223d61c7e9fb9fe54eac35f16160b2</email>
                  <email type="domain">cnrs.fr</email>
                  <idno type="idhal" notation="string">laure-gibot</idno>
                  <idno type="idhal" notation="numeric">184501</idno>
                  <idno type="halauthorid" notation="string">10563-184501</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7255-4123</idno>
                  <idno type="IDREF">https://www.idref.fr/117481483</idno>
                  <affiliation ref="#struct-756"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Heinz</forename>
                    <surname>Amenitisch</surname>
                  </persName>
                  <idno type="halauthorid">2997594-0</idno>
                  <affiliation ref="#struct-65509"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lorenzo</forename>
                    <surname>Cervelli</surname>
                  </persName>
                  <idno type="halauthorid">2997595-0</idno>
                  <affiliation ref="#struct-192129"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Costanza</forename>
                    <surname>Montis</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">795497</idno>
                  <idno type="halauthorid" notation="string">1609570-795497</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6960-3772</idno>
                  <affiliation ref="#struct-192129"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Barbara</forename>
                    <surname>Lonetti</surname>
                  </persName>
                  <email type="md5">00ff46e851e284f70869fe3de6cf8cd7</email>
                  <email type="domain">chimie.ups-tlse.fr</email>
                  <idno type="idhal" notation="string">barbara-lonetti</idno>
                  <idno type="idhal" notation="numeric">1251898</idno>
                  <idno type="halauthorid" notation="string">126583-1251898</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4291-6861</idno>
                  <idno type="IDREF">https://www.idref.fr/18584796X</idno>
                  <idno type="VIAF">https://viaf.org/viaf/316670420</idno>
                  <affiliation ref="#struct-756"/>
                  <affiliation ref="#struct-1178841"/>
                  <affiliation ref="#struct-1178837"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Debora</forename>
                    <surname>Berti</surname>
                  </persName>
                  <idno type="halauthorid">1609569-0</idno>
                  <affiliation ref="#struct-192129"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">11892</idno>
                <idno type="issn">0927-7765</idno>
                <idno type="eissn">1873-4367</idno>
                <title level="j">Colloids and Surfaces B: Biointerfaces</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">231</biblScope>
                  <biblScope unit="pp">113532</biblScope>
                  <date type="datePub">2023-11</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.colsurfb.2023.113532</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Copolymer</term>
                <term xml:lang="en">Self-assembly</term>
                <term xml:lang="en">Drug delivery</term>
                <term xml:lang="en">Cubosomes</term>
              </keywords>
              <classCode scheme="halDomain" n="chim">Chemical Sciences</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>In recent years, lipid cubic nanoparticles have emerged as promising nanocarriers for drug delivery, due to the several advantages they exhibit with respect to other lipid systems. Here, we report on lipid cubic nanoparticles stabilized by PNIPAM-based amphiphilic block copolymers, specifically, poly(N, N-dimethylacrylamide)-block-poly(N-isopropylacrylamide) (PDMA-b-PNIPAM), as a new class of drug delivery systems (DDS). In vitro studies on the internalization efficiency of the DDS towards two types of human cancer cells (colon HCT-116 and bladder T24 cells), carried out employing a set of sensitive techniques (confocal laser scanning microscopy (CLSM), flow cytometry, scanning electron microscopy (SEM), fluorescence spectroscopy), highlight a prominent role of PDMA-b-PNIPAM stabilizer in enhancing the uptake of cubosomes, compared to the standard Pluronic F127-based formulations. The drug delivery potential of cubosomes, tested by encapsulating a chemotherapeutic drug, camptothecin (CPT), and conducting cytotoxicity studies against 2D plated cells and 3D spheroids, confirm that PDMA-b-PNIPAM-stabilized cubosomes improve the efficacy of treatment with CPT. The origin of this effect lies in the higher lipophilicity of the stabilizer, as we confirm by studying the interaction between the cubosomes and biomimetic membranes of lipid vesicles with Small Angle X-Ray Scattering (SAXS) and CLSM experiments. These results corroborate our fundamental understanding of the interaction between cubosomes and cells, and on the role of polymer to formulate lipid cubic nanoparticles as DDS.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="regrouplaboratory" xml:id="struct-192129" status="VALID">
          <orgName>Dipartimento di Chimica "Ugo Schiff" = Department of Chemistry “Ugo Schiff” = Département de Chimie "Ugo Schiff"</orgName>
          <orgName type="acronym">DICUS UniFI</orgName>
          <desc>
            <address>
              <addrLine>Department of Chemistry [Florence] / Università degli Studi di Firenze — Via della Lastruccia, 13 - 50019 Sesto Fiorentino (FI)</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.chim.unifi.it/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-148408" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-756" status="OLD">
          <idno type="IdRef">238305007</idno>
          <idno type="RNSR">199512052B</idno>
          <idno type="ROR">https://ror.org/0171mae58</idno>
          <orgName>Interactions moléculaires et réactivité chimique et photochimique</orgName>
          <orgName type="acronym">IMRCP</orgName>
          <date type="start">1995-01-01</date>
          <date type="end">2023-09-01</date>
          <desc>
            <address>
              <addrLine>Bat. 2R1 RECHERCHE DE CHIMIE 118 Route de Narbonne 31062 TOULOUSE CEDEX 4</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://imrcp.ups-tlse.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-159253" type="direct"/>
            <relation active="#struct-67872" type="indirect"/>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UAR2599 / FR2599" active="#struct-441569" type="direct"/>
            <relation active="#struct-448187" type="indirect"/>
            <relation active="#struct-166355" type="direct"/>
            <relation name="INS1650" active="#struct-441569" type="direct"/>
            <relation name="UMR5623" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-65509" status="VALID">
          <idno type="ROR">https://ror.org/00d7xrm67</idno>
          <orgName>Graz University of Technology [Graz]</orgName>
          <orgName type="acronym">TU Graz</orgName>
          <desc>
            <address>
              <addrLine>Rechbauerstr. 12,  8010 Graz</addrLine>
              <country key="AT"/>
            </address>
            <ref type="url">https://www.tugraz.at/en/home/</ref>
          </desc>
        </org>
        <org type="researchteam" xml:id="struct-1178841" status="OLD">
          <orgName>Interfaces Dynamiques et Assemblages Stimulables</orgName>
          <orgName type="acronym">IDeAS</orgName>
          <date type="start">2023-09-01</date>
          <date type="end">2023-12-31</date>
          <desc>
            <address>
              <addrLine>Bat. 2R1 118 Route de Narbonne 31062 TOULOUSE CEDEX 4</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://imrcp.ups-tlse.fr/fr/page/l%C3%A9quipe-ideas-j-d-marty-n-lauth-de-viguerie</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1178837" type="direct"/>
            <relation active="#struct-159253" type="indirect"/>
            <relation active="#struct-67872" type="indirect"/>
            <relation active="#struct-217752" type="indirect"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-341038" type="indirect"/>
            <relation name="UAR2599 / FR2599" active="#struct-441569" type="indirect"/>
            <relation active="#struct-448187" type="indirect"/>
            <relation active="#struct-166355" type="indirect"/>
            <relation name="INS1650" active="#struct-441569" type="indirect"/>
            <relation name="UMR5623" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1178837" status="OLD">
          <idno type="IdRef">238305007</idno>
          <idno type="RNSR">199512052B</idno>
          <orgName>Chimie des colloïdes, polymères &amp; assemblages complexes</orgName>
          <orgName type="acronym">Softmat</orgName>
          <date type="start">2023-09-01</date>
          <date type="end">2023-12-31</date>
          <desc>
            <address>
              <addrLine>Bat. 2R1 RECHERCHE DE CHIMIE 118 Route de Narbonne 31062 TOULOUSE CEDEX 4</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-159253" type="direct"/>
            <relation active="#struct-67872" type="indirect"/>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UAR2599 / FR2599" active="#struct-441569" type="direct"/>
            <relation active="#struct-448187" type="indirect"/>
            <relation active="#struct-166355" type="direct"/>
            <relation name="INS1650" active="#struct-441569" type="direct"/>
            <relation name="UMR5623" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-148408" status="VALID">
          <idno type="IdRef">026430584</idno>
          <idno type="ROR">https://ror.org/04jr1s763</idno>
          <orgName>Università degli Studi di Firenze = University of Florence = Université de Florence</orgName>
          <orgName type="acronym">UniFI</orgName>
          <desc>
            <address>
              <addrLine>Piazza di San Marco, 4, 50121 Firenze FI, Italie</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.unifi.it/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-159253" status="OLD">
          <idno type="IdRef">240309472</idno>
          <idno type="ISNI">0000 0004 4686 8315</idno>
          <idno type="RNSR">200310667L</idno>
          <orgName>Institut de Chimie de Toulouse</orgName>
          <orgName type="acronym">ICT</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-67872" type="direct"/>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UAR2599 / FR2599" active="#struct-441569" type="direct"/>
            <relation active="#struct-448187" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-67872" status="VALID">
          <idno type="IdRef">050165224</idno>
          <idno type="ROR">https://ror.org/05q3vnk25</idno>
          <orgName>Institut de Recherche pour le Développement</orgName>
          <orgName type="acronym">IRD</orgName>
          <desc>
            <address>
              <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ird.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-448187" status="VALID">
          <idno type="IdRef">026388820</idno>
          <idno type="ISNI">0000000121766169</idno>
          <idno type="ROR">https://ror.org/033p9g875</idno>
          <orgName>Institut National Polytechnique (Toulouse)</orgName>
          <orgName type="acronym">Toulouse INP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.inp-toulouse.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-166355" status="VALID">
          <idno type="IdRef">163530912</idno>
          <idno type="ISNI">0000000102537563</idno>
          <idno type="ROR">https://ror.org/01q76b368</idno>
          <orgName>Institut Ecologie et Environnement - CNRS Ecologie et Environnement</orgName>
          <orgName type="acronym">INEE-CNRS</orgName>
          <date type="start">2009-11-01</date>
          <desc>
            <address>
              <addrLine>3 rue Michel-Ange, 75794, Paris cedex 16, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.inee.cnrs.fr/fr</ref>
          </desc>
          <listRelation>
            <relation name="INS1650" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-50804" status="VALID">
          <idno type="anr">ANR-17-EURE-0009</idno>
          <orgName>NanoX</orgName>
          <desc>Science et Ingénierie à l'Echelle Nano</desc>
          <date type="start">2017</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>