First experimental evidence of peritoneal and pleural mesotheliomas induced by fluoro-edenite fibres present in Etnean volcanic material from Biancavilla (Sicily, Italy) - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue European Journal of Oncology Année : 2004

First experimental evidence of peritoneal and pleural mesotheliomas induced by fluoro-edenite fibres present in Etnean volcanic material from Biancavilla (Sicily, Italy)

Franco Minardi
  • Fonction : Auteur
Luciano Bua
  • Fonction : Auteur
Davide Degli Esposti
Fiorella Belpoggi
  • Fonction : Auteur

Résumé

A total of 17 cases of pleural mesothelioma were ascertained in the town of Biancavilla (Sicily, Italy), on the southwest slopes of the volcano Etna, from 1980 to 1997. Occupational exposure to asbestos was considered possible in only 2 of them, though it could not be excluded in 5 other cases: for the remaining 10 cases the hypothesis of environmental exposure was deemed reasonable. On the basis of this evaluation, a mineralogic study was started in the area of Biancavilla, where incohesive volcanic material has largely been used in the building industry and road paving since the 1960s-1970s. This study led to the identification of the new fluoro-edenite amphibole with prismatic, acicular and fibrous asbestiform morphologies. With a view to acquiring more detailed information on the possible causal relationship between exposure to this mineral and the onset of mesotheliomas, the mineral was tested, by a single intraperitoneal or intrapleural injection, on groups of 80 Sprague-Dawley rats (40 males and 40 females) (fibrous fluoroedenite) and on a group of 30 rats (15 males and 15 females) (powdered prismatic fluoro-edenite), 8 weeks old at the start of the study, at a dose of 25 mg in 1 cc of water; 1 cc of water was administered by intraperitoneal injection to 80 rats (controls). One hundred and nine weeks after the treatment, a high incidence of peritoneal and, to a lesser extent, pleural mesotheliomas was observed in the animals treated with fibrous fluoroedenite; this incidence is comparable to that obtained with various kinds of asbestos. Up to now no cases of mesothelioma have been observed in the group treated with prismatic fluoro-edenite, or in the control group. Eur. J. Oncol., 9 (3), 169-175, 2004
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hal-04359150 , version 1 (21-12-2023)

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  • HAL Id : hal-04359150 , version 1

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Morando Soffritti, Franco Minardi, Luciano Bua, Davide Degli Esposti, Fiorella Belpoggi. First experimental evidence of peritoneal and pleural mesotheliomas induced by fluoro-edenite fibres present in Etnean volcanic material from Biancavilla (Sicily, Italy). European Journal of Oncology, 2004. ⟨hal-04359150⟩
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