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Article Dans Une Revue PLoS Medicine Année : 2023

Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies

Johan L. Vinther
  • Fonction : Auteur
Tim Cadman
  • Fonction : Auteur
Demetris Avraam
  • Fonction : Auteur
Claus T. Ekstrøm
  • Fonction : Auteur
Thorkild I. A. Sørensen
  • Fonction : Auteur
Ahmed Elhakeem
  • Fonction : Auteur
Ana C. Santos
  • Fonction : Auteur
Angela Pinot de Moira
  • Fonction : Auteur
Barbara Heude
  • Fonction : Auteur
Carmen Iñiguez
  • Fonction : Auteur
Costanza Pizzi
  • Fonction : Auteur
Elinor Simons
  • Fonction : Auteur
Ellis Voerman
  • Fonction : Auteur
Eva Corpeleijn
  • Fonction : Auteur
Gilian Santorelli
  • Fonction : Auteur
Hazel Inskip
  • Fonction : Auteur
Henrique Barros
  • Fonction : Auteur
Jennie Carson
  • Fonction : Auteur
Jennifer R. Harris
  • Fonction : Auteur
Johanna L. T. Nader
  • Fonction : Auteur
Justiina Ronkainen
  • Fonction : Auteur
Katrine Strandberg-Larsen
  • Fonction : Auteur
Loreto Santa Marina
  • Fonction : Auteur
Lucinda Calas
  • Fonction : Auteur
Luise Cederkvist
  • Fonction : Auteur
Maja Popovic
  • Fonction : Auteur
Marieke Welten
  • Fonction : Auteur
Martine Vrijheid
  • Fonction : Auteur
Meghan Azad
  • Fonction : Auteur
Padmaja Subbarao
  • Fonction : Auteur
Paul Burton
  • Fonction : Auteur
Puishkumar J. Mandhane
  • Fonction : Auteur
Rae-Chi Huang
  • Fonction : Auteur
Rebecca C. Wilson
  • Fonction : Auteur
Sido Haakma
  • Fonction : Auteur
Sílvia Fernández-Barrés
  • Fonction : Auteur
Stuart Turvey
  • Fonction : Auteur
Susana Santos
  • Fonction : Auteur
Suzanne C. Tough
  • Fonction : Auteur
Sylvain Sebert
  • Fonction : Auteur
Theo J. Moraes
  • Fonction : Auteur
Theodosia Salika
  • Fonction : Auteur
Vincent W. V. Jaddoe
  • Fonction : Auteur
Deborah A. Lawlor
  • Fonction : Auteur
Anne-Marie Nybo Andersen
  • Fonction : Auteur

Résumé

Background Preterm birth is the leading cause of perinatal morbidity and mortality and is associated with adverse developmental and long-term health outcomes, including several cardiometabolic risk factors and outcomes. However, evidence about the association of preterm birth with later body size derives mainly from studies using birth weight as a proxy of prematurity rather than an actual length of gestation. We investigated the association of gestational age (GA) at birth with body size from infancy through adolescence. Methods and findings We conducted a two-stage individual participant data (IPD) meta-analysis using data from 253,810 mother–child dyads from 16 general population-based cohort studies in Europe (Denmark, Finland, France, Italy, Norway, Portugal, Spain, the Netherlands, United Kingdom), North America (Canada), and Australasia (Australia) to estimate the association of GA with body mass index (BMI) and overweight (including obesity) adjusted for the following maternal characteristics as potential confounders: education, height, prepregnancy BMI, ethnic background, parity, smoking during pregnancy, age at child’s birth, gestational diabetes and hypertension, and preeclampsia. Pregnancy and birth cohort studies from the LifeCycle and the EUCAN-Connect projects were invited and were eligible for inclusion if they had information on GA and minimum one measurement of BMI between infancy and adolescence. Using a federated analytical tool (DataSHIELD), we fitted linear and logistic regression models in each cohort separately with a complete-case approach and combined the regression estimates and standard errors through random-effects study-level meta-analysis providing an overall effect estimate at early infancy (>0.0 to 0.5 years), late infancy (>0.5 to 2.0 years), early childhood (>2.0 to 5.0 years), mid-childhood (>5.0 to 9.0 years), late childhood (>9.0 to 14.0 years), and adolescence (>14.0 to 19.0 years). GA was positively associated with BMI in the first decade of life, with the greatest increase in mean BMI z-score during early infancy (0.02, 95% confidence interval (CI): 0.00; 0.05, p < 0.05) per week of increase in GA, while in adolescence, preterm individuals reached similar levels of BMI (0.00, 95% CI: −0.01; 0.01, p 0.9) as term counterparts. The association between GA and overweight revealed a similar pattern of association with an increase in odds ratio (OR) of overweight from late infancy through mid-childhood (OR 1.01 to 1.02) per week increase in GA. By adolescence, however, GA was slightly negatively associated with the risk of overweight (OR 0.98 [95% CI: 0.97; 1.00], p 0.1) per week of increase in GA. Although based on only four cohorts (n = 32,089) that reached the age of adolescence, data suggest that individuals born very preterm may be at increased odds of overweight (OR 1.46 [95% CI: 1.03; 2.08], p < 0.05) compared with term counterparts. Findings were consistent across cohorts and sensitivity analyses despite considerable heterogeneity in cohort characteristics. However, residual confounding may be a limitation in this study, while findings may be less generalisable to settings in low- and middle-income countries. Conclusions This study based on data from infancy through adolescence from 16 cohort studies found that GA may be important for body size in infancy, but the strength of association attenuates consistently with age. By adolescence, preterm individuals have on average a similar mean BMI to peers born at term.
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hal-04355604 , version 1 (20-12-2023)

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Johan L. Vinther, Tim Cadman, Demetris Avraam, Claus T. Ekstrøm, Thorkild I. A. Sørensen, et al.. Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies. PLoS Medicine, 2023, 20 (4), pp.e1004036. ⟨10.1371/journal.pmed.1004036⟩. ⟨hal-04355604⟩
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