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Article Dans Une Revue Trends in Parasitology Année : 2023

Plasmodium falciparum ring-stage plasticity and drug resistance

Résumé

Highlights Plasmodium falciparum has evolved resistance to almost all antimalarial drugs through genomic changes –SNPs and copy number variants (CNVs) – and a nonspecific stress-response-based survival such as the ring-stage temporary growth arrest (TGA). The ring-stage can develop into asexual or sexual stages or stop growing when conditions are unfavorable. The ring-stage shows extreme plasticity under adverse conditions, such as artemisinin exposure. The ring-stage TGA stage exhibits an innate and passive resistance to many stressors, which ensures that some individuals in the population can survive in the host. P. falciparum ring-stage TGA may rely on environmental sensing and extracellular communication between the parasites. Ring-stage TGA may be an underestimated parasite reservoir, especially in asymptomatic individuals. No treatment that specifically targets growth-arrested ring stages is currently available.
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Dates et versions

hal-04355178 , version 1 (20-12-2023)

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Lucien Platon, Didier Ménard. Plasmodium falciparum ring-stage plasticity and drug resistance. Trends in Parasitology, inPress, ⟨10.1016/j.pt.2023.11.007⟩. ⟨hal-04355178⟩
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