Effect of cyclodextrin complexation on phenylpropanoids' solubility and antioxidant activity - Archive ouverte HAL
Article Dans Une Revue Beilstein Journal of Organic Chemistry Année : 2014

Effect of cyclodextrin complexation on phenylpropanoids' solubility and antioxidant activity

Résumé

The complexation abilities of five cyclodextrins (CDs) with seven phenylpropanoids (PPs) were evaluated by UV???visible spectroscopy, phase solubility studies and molecular modeling. Formation constants ( ), complexation efficiency (CE), PP:CD molar ratio, increase in formulation bulk and complexation energy were assessed. All complexes exhibited a 1:1 stoichiometry but their stability was influenced by the nature and the position of the phenyl ring substituents. A relationship between the intrinsic solubility of guests ( ) and the solubilizing potential of CD was proposed. Molecular modeling was used to investigate the complementarities between host and guest. Finally, the antioxidant activity of encapsulated PPs was evaluated by scavenging of the stable DPPH radical.
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Dates et versions

hal-04351341 , version 1 (18-12-2023)

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Lizette Auezova, Hélène Greige-Gerges, Sophie Fourmentin, Miriana Kfoury, David Landy. Effect of cyclodextrin complexation on phenylpropanoids' solubility and antioxidant activity. Beilstein Journal of Organic Chemistry, 2014, 10, pp.2322 - 2331. ⟨10.3762/bjoc.10.241⟩. ⟨hal-04351341⟩
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