A tridimensional atlas of the developing human head - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cell Année : 2023

A tridimensional atlas of the developing human head

Raphael Blain
Gérard Couly
  • Fonction : Auteur
  • PersonId : 1020959
Eimad Shotar
  • Fonction : Auteur
  • PersonId : 1083686
Megumi Inoue
Frédéric Clarençon
Paolo Giacobini
  • Fonction : Auteur
  • PersonId : 1056024
Yorick Gitton
Connectez-vous pour contacter l'auteur
Alain Chédotal

Résumé

The evolution and development of the head have long captivated researchers due to the crucial role of the head as the gateway for sensory stimuli and the intricate structural complexity of the head. Although significant progress has been made in understanding head development in various vertebrate species, our knowledge of early human head ontogeny remains limited. Here, we used advanced whole-mount immunostaining and 3D imaging techniques to generate a comprehensive 3D cellular atlas of human head embryogenesis. We present detailed developmental series of diverse head tissues and cell types, including muscles, vasculature, cartilage, peripheral nerves, and exocrine glands. These datasets, accessible through a dedicated web interface, provide insights into human embryogenesis. We offer perspectives on the branching morphogenesis of human exocrine glands and unknown features of the development of neurovascular and skeletomuscular structures. These insights into human embryology have important implications for understanding craniofacial defects and neurological disorders and advancing diagnostic and therapeutic strategies.

Dates et versions

hal-04341975 , version 1 (13-12-2023)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Raphael Blain, Gérard Couly, Eimad Shotar, Joséphine Blévinal, Maryne Toupin, et al.. A tridimensional atlas of the developing human head. Cell, 2023, Cell, ⟨10.1016/j.cell.2023.11.013⟩. ⟨hal-04341975⟩
22 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More