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Communication Dans Un Congrès Année : 2019

Design of biobased nanoparticles through polymerization induced self-assembly of biosourced monomers

Fanny Coumes
Mauricio Balarezo
  • Fonction : Collaborateur
  • PersonId : 1231245
  • IdRef : 268065977
François Stoffelbach

Résumé

From a global point of view, the development of greener processes and the use of “greener” building blocks are one of the main challenges that synthetic chemists must address to solve current environmental and economic issues. Polymers represent an important class of materials widely used in industrial applications. Nevertheless, apart from natural polymers, synthetic polymers are essentially based on petrosourced monomers. To achieve sustainable chemistry, several teams are currently investigating the synthesis of biosourced polymers.1–3 In our group, we decided to combine the use of the polymerization induced-self-assembly (PISA) technique and reversible-deactivation radical polymerization (RDRP) in green solvents (ultimately in water) to engineer nanoparticles (NPs) based on new biobased amphiphilic copolymers. While the RDRP -such as the radical addition-fragmentation transfer (RAFT) polymerization - allows the preparation of defined polymers in a controlled fashion4, the PISA approach, proceeding in heterogeneous potentially “green” conditions, relying on the use of a hydrophilic macromolecular control agent to promote the polymerization of hydrophobic monomers, leads to the formation of amphiphilic block copolymers that self-assemble into self-stabilized nanoparticles (NPs), avoiding the use of any free surfactant in the medium.5,6 In this work, hydrophobic and hydrophilic biobased radically polymerizable monomers were either purchased or designed from biosourced precursors. Then, a hydrophilic biobased reactive block, namely a macro-RAFT agent, was used in the PISA approach to generate completely biosourced NPs. The polymerization conditions were varied (concentration of the hydrophobic monomer, DP targeted) in order to achieve the in situ formation of various morphologies. Kinetic studies were performed to assess the control of the polymerization using 1H NMR and size-exclusion chromatography (SEC). Then, the shape and size of the NPs were assessed by means of dynamic light scattering (DLS) and cryo-transmission electronic microscopy (cryo-TEM) Since various potential applications of PISA NPs have already been described in the literature, ranging from biomedical applications to reinforcement agents for materials7, physico-chemical studies of our biobased NPs will be done shortly. References : [1] Molina-Gutierrez, S.; Ladmiral, V.; Bongiovanni, R. M.; Caillol, S.; Lacroix-Desmazes, P. Green Chem. 2019, 21, 36–53. [2] Thomsett, M. R.; Moore, J. C.; Buchard, A.; Stockman, R. A.; Howdle, S. M. Green Chem. 2019, 21 (1), 149–156. [3] Li, W. S. J.; Negrell, C.; Ladmiral, V.; Lai-Kee-Him, J.; Bron, P.; Lacroix-Desmazes, P.; Joly-Duhamel, C.; Caillol, S. Polym. Chem. 2018, 9 (18), 2468–2477. [4] Semsarilar, M.; Perrier, S. Nat. Chem. 2010, 2 (10), 811–820. [5] Rieger, J. Macromol. Rapid Commun. 2015, 36 (16), 1458–1471. [6] Lansalot, M.; Rieger, J. Macromol. Rapid Commun. 2019, 40 (2), 1–3. [7] Albigès, R.; Klein, P.; Roi, S.; Stoffelbach, F.; Creton, C.; Bouteiller, L.; Rieger, J. Polym. Chem. 2017, 8 (34), 4992–4995.

Domaines

Chimie
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Dates et versions

hal-04338957 , version 1 (12-12-2023)

Identifiants

  • HAL Id : hal-04338957 , version 1

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Fanny Coumes, Mauricio Balarezo, Jutta Rieger, François Stoffelbach. Design of biobased nanoparticles through polymerization induced self-assembly of biosourced monomers. 48ème colloque national du groupe français des polymères, Nov 2019, Mulhouse, France. ⟨hal-04338957⟩
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