Cumulative detection of anal high-grade squamous intraepithelial lesions over two-year follow-up in men who have sex with men living with HIV in France - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Infectious Diseases Année : 2023

Cumulative detection of anal high-grade squamous intraepithelial lesions over two-year follow-up in men who have sex with men living with HIV in France

Sylvie Radenne

Résumé

We assessed cumulative detection and determinants of anal high-grade squamous intraepithelial lesions (HSIL) in men who have sex with men living with HIV who underwent three visits over two years, with cytology and high-resolution anoscopy (HRA), within the ANRS-EP57-APACHES study. Cumulative HSIL detection was 33% (134/410), of which 48% were detected at baseline. HSIL detection varied considerably by center (13-51%). Strongest HSIL determinants were baseline HPV16 (adjusted odds ratio [aOR] 8.2; 95% confidence interval [95%CI] 3.6-18.9), and p16/Ki67 (aOR 4.6; 95%CI 2.3-9.1). Repeat annual cytology and HRA improved HSIL detection but did not fully compensate between-center heterogeneity.
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Dates et versions

hal-04338038 , version 1 (12-12-2023)

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Jean-Damien Combes, Jean-Michel Didelot, Sylvie Radenne, Olivia Zaegel-Faucher, Anne-Carole Lesage, et al.. Cumulative detection of anal high-grade squamous intraepithelial lesions over two-year follow-up in men who have sex with men living with HIV in France. Journal of Infectious Diseases, 2023, Journal of Infectious Diseases, pp.jiad506. ⟨10.1093/infdis/jiad506⟩. ⟨hal-04338038⟩
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