Oral microbiota in cancer: could the bad guy turn good with application of polyphenols? - Archive ouverte HAL
Article Dans Une Revue Expert Reviews in Molecular Medicine Année : 2022

Oral microbiota in cancer: could the bad guy turn good with application of polyphenols?

Mariya Gover Antoniraj
  • Fonction : Auteur
Kasi Pandima Devi
  • Fonction : Auteur
Ioana Berindan-Neagoe
  • Fonction : Auteur
Seyed Fazel Nabavi
  • Fonction : Auteur
Hamid Reza Khayat Kashani
  • Fonction : Auteur
Safieh Aghaabdollahian
  • Fonction : Auteur
Farzaneh Afkhami
  • Fonction : Auteur
Zahra Lorigooini
  • Fonction : Auteur
Maryam Khayatkashani
  • Fonction : Auteur
Seyed Mohammad Nabavi

Résumé

Abstract The human oral cavity is comprised of dynamic and polynomial microbes which uniquely reside in the microenvironments of oral cavities. The cumulative functions of the symbiotic microbial communities maintain normal homeostasis; however, a shifted microbiota yields a dysbiosis state, which produces local and systemic diseases including dental caries, periodontitis, cancer, obesity and diabetes. Recent research reports claim that an association occurs between oral dysbiosis and the progression of different types of cancers including oral, gastric and pancreatic ones. Different mechanisms are proposed for the development of cancer, such as induction of inflammatory reactions, production of carcinogenic materials and alteration of the immune system. Medications are available to treat these associated diseases; however, the current strategies may further worsen the disease by unwanted side effects. Natural-derived polyphenol molecules significantly inhibit a wide range of systemic diseases with fewer side effects. In this review, we have displayed the functions of the oral microbes and we have extended the report regarding the role of polyphenols in oral microbiota to maintain healthy conditions and prevention of diseases with emphasis on the treatment of oral microbiota-associated cancer.
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Dates et versions

hal-04335839 , version 1 (11-12-2023)

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Citer

Mariya Gover Antoniraj, Kasi Pandima Devi, Ioana Berindan-Neagoe, Seyed Fazel Nabavi, Hamid Reza Khayat Kashani, et al.. Oral microbiota in cancer: could the bad guy turn good with application of polyphenols?. Expert Reviews in Molecular Medicine, 2022, Frontiers Research Topics, 25, pp.e1. ⟨10.1017/erm.2022.39⟩. ⟨hal-04335839⟩

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