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Article Dans Une Revue Atherosclerosis Année : 2003

IL-6, TNF-α and atherosclerosis risk indicators in a healthy family population: the STANISLAS cohort

Résumé

There are no satisfactory data on circulating concentrations of inflammatory cytokines and their potential relationship with traditional and nontraditional atherosclerosis risk factors in a large healthy young population. The present study was conducted to examine, in 179 healthy families selected from the STANISLAS cohort, the association between interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), orosomucoid, haptoglobin, cell-adhesion molecules (ICAM-1, E-, L- and P-selectin) and lipid parameter concentrations. Age, BMI, white blood cells and tobacco consumption contributed to the variation of IL-6 concentrations. Age and tobacco contributed also to TNF-α variation. Taking into account potential covariates, we showed strong positive correlation between IL-6 and both inflammatory markers TNF-α and CRP in parents and in offspring (P<0.001). In parents, IL-6 was associated with ICAM-1 and L-selectin (P<0.01), while IL-6 and TNF-α predicted E-selectin in offspring only (0.001

Dates et versions

hal-04335440 , version 1 (11-12-2023)

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Nadia Haddy, Catherine Sass, Suzanne Droesch, Mohamed Zaiou, Gérard Siest, et al.. IL-6, TNF-α and atherosclerosis risk indicators in a healthy family population: the STANISLAS cohort. Atherosclerosis, 2003, 170 (2), pp.277-283. ⟨10.1016/s0021-9150(03)00287-9⟩. ⟨hal-04335440⟩

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