Emergency Medical Service (EMS) managers continuously strive to improve the coverage performance, i.e., the percentage of calls responded to within a specific target time, to save lives in case of life-threatening emergencies. This goal can be achieved by dynamically adjusting the location of rescue teams during a day in response to some temporal or geographical fluctuations such as demand patterns, traffic conditions, or the number of teams on duty. This relocation is known as the multi-period redeployment problem. In this study, we propose a discrete simulation-based optimization model to adress the multi-period redeployment problem in the French EMS of the Val-de-Marne department (France), named SAMU 94. The proposed model uses an iterative method that combines the use of a mathematical model to find the optimal locations of rescue teams with the use of the SAMU 94 simulation model implemented in Arena software, to evaluate the busy fraction parameters required to solve the mathematical model. The model performance was compared with that of the simulation-based optimization software, OptQuest. The experimental results demonstrated that the iterative method could produce solutions with better coverage performance, 20 times faster than OptQues