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Article Dans Une Revue Clinical and Translational Medicine Année : 2023

Malaria in the horn of Africa: The ongoing battle against drug resistance [commentary]

Résumé

Malaria, an infectious disease caused by Plasmodium parasites transmitted by Anopheles mosquitoes, is a significant global public health concern, having reportedly claimed the lives–50-60 billion people1. Despite considerable progress having been made, Plasmodium falciparum, which is responsible for its severe forms, remains highly prevalent in sub-Saharan Africa. In 2021, 247 million cases and 619,000 deaths were reported, representing an increase of 6.4% compared with 2019.2 Currently, the most pressing concern is the emergence of antimalarial drug resistance, which poses a significant obstacle to effective treatment and control.2 A recent publication in the New England Journal of Medicine entitled ‘Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea’,3 provides worrying evidence of the emergence and spread of parasites in the Horn of Africa with both artemisinin partial resistance (ART-R) and genome modifications that prevent their detection by rapid diagnostic tests (RDTs), threatening malaria control and elimination campaigns in the region and potentially elsewhere in Africa.
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hal-04329310 , version 1 (11-12-2023)

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Lucien Platon, Qingfeng Zhang, Jun Cao, Didier Ménard. Malaria in the horn of Africa: The ongoing battle against drug resistance [commentary]. Clinical and Translational Medicine, 2023, 13 (11), pp.e1482. ⟨10.1002/ctm2.1482⟩. ⟨hal-04329310⟩
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