New method to discriminate sedative and analgesic effects of drugs in the automated formalin test in rats - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Neuroscience Research Année : 2012

New method to discriminate sedative and analgesic effects of drugs in the automated formalin test in rats

Stéphanie Grégoire
  • Fonction : Auteur
Monique Etienne
  • Fonction : Auteur
Marie Gaulmin
  • Fonction : Auteur
François Caussade
  • Fonction : Auteur
Didier Neuzeret
  • Fonction : Auteur
Denis Ardid
  • Fonction : Auteur

Résumé

We developed an automated technique based on the detection of pain-related behaviours (like licking or biting) and small activities (mostly grooming) in the formalin pain test. By comparing automated and manual scoring, we determined that the interphase score was mostly independent of pain-related behaviours and it was used as an index of sedative events. The non-pain-related behaviours, still present during the second phase, were eliminated in order to visualize only pain-related behaviours. This new method, validated using classical analgesic (morphine) and sedative drugs (diazepam) could be used to discriminate sedative from analgesic effects of pharmacological treatments in the formalin test.

Dates et versions

hal-04317458 , version 1 (01-12-2023)

Identifiants

Citer

Stéphanie Grégoire, Monique Etienne, Marie Gaulmin, François Caussade, Didier Neuzeret, et al.. New method to discriminate sedative and analgesic effects of drugs in the automated formalin test in rats. Neuroscience Research, 2012, 72 (2), pp.194-198. ⟨10.1016/j.neures.2011.10.004⟩. ⟨hal-04317458⟩

Collections

PRES_CLERMONT ND
11 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More