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Article Dans Une Revue Journal of Magnetism and Magnetic Materials Année : 2024

Silica-coated magnetic nanorods with zwitterionic surface functionalization to overcome non-specific protein adsorption

Résumé

Anisotropic magnetic nanoparticles are receiving growing interest for biomedical applications due to their interesting properties, particularly for MRI and magnetic hyperthermia. In this work, a two-step, relatively simple synthesis pathway of magnetite nanorods was optimised. A ligand from the catechol family, known for its high iron oxide surface affinity, was used to transfer them into aqueous phase. The magnetite nanorods were then coated with a layer of fluorescent silica, whose surface was functionalised in two ways: either by short poly(ethylene glycol) (PEG) chains or by sulfobetaine zwitterionic molecules. A wide range of techniques were used to thoroughly characterise their physical structure, magnetic properties and dispersion characteristics. Finally, a study of the adsorption of a fluorescent model protein revealed that zwitterionic sulfobetaine molecules were more effective than PEG chains in limiting the non-specific adsorption of this protein.
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hal-04315807 , version 1 (30-11-2023)

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Sirine El Mousli, Yvonne Dorant, Enzo Bertuit, Emilie Secret, Jean-Michel Siaugue. Silica-coated magnetic nanorods with zwitterionic surface functionalization to overcome non-specific protein adsorption. Journal of Magnetism and Magnetic Materials, 2024, 589, pp.171571. ⟨10.1016/j.jmmm.2023.171571⟩. ⟨hal-04315807⟩
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