Lewis‐Acidic Polyoxometalates as Reusable Catalysts for the Synthesis of Glucuronic Acid Esters under Microwave Irradiation
Résumé
D-Glucuronic acid (GlcA) is an ubiquitous compound of oligo-and polysaccharides of biological importance. GlcA derivatives have been prepared for several applications, as surface-active compounds [1,2] or as bioactive molecules. [3] Glucuronidation is a well-known drug-metabolizing reaction and is generally regarded as a detoxification process. Glucopyranuronate derivatives have been used as glycosyl donors for glucuronidation of pharmacological active compounds to form synthetic glucuronides which were compared to natural metabolites. [4] Recently the synthesis of nontoxic prodrugs has been extensively studied as a strategy in cancer therapy for application in Antibody Directed Enzyme Prodrug Therapy (ADEPT) [5] or in Prodrug Monotherapy (PMT). [6] These prodrugs are synthesized for the most from imidate glucuronate derivatives or ester glucuronates with free anomeric hydroxyls.
Domaines
ChimieOrigine | Fichiers produits par l'(les) auteur(s) |
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