Lewis‐Acidic Polyoxometalates as Reusable Catalysts for the Synthesis of Glucuronic Acid Esters under Microwave Irradiation - Archive ouverte HAL
Article Dans Une Revue ChemSusChem Année : 2010

Lewis‐Acidic Polyoxometalates as Reusable Catalysts for the Synthesis of Glucuronic Acid Esters under Microwave Irradiation

Résumé

D-Glucuronic acid (GlcA) is an ubiquitous compound of oligo-and polysaccharides of biological importance. GlcA derivatives have been prepared for several applications, as surface-active compounds [1,2] or as bioactive molecules. [3] Glucuronidation is a well-known drug-metabolizing reaction and is generally regarded as a detoxification process. Glucopyranuronate derivatives have been used as glycosyl donors for glucuronidation of pharmacological active compounds to form synthetic glucuronides which were compared to natural metabolites. [4] Recently the synthesis of nontoxic prodrugs has been extensively studied as a strategy in cancer therapy for application in Antibody Directed Enzyme Prodrug Therapy (ADEPT) [5] or in Prodrug Monotherapy (PMT). [6] These prodrugs are synthesized for the most from imidate glucuronate derivatives or ester glucuronates with free anomeric hydroxyls.

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Chimie
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hal-04315445 , version 1 (30-11-2023)

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Michael Bosco, Stéphanie Rat, Nathalie Dupré, Bernold Hasenknopf, Emmanuel Lacôte, et al.. Lewis‐Acidic Polyoxometalates as Reusable Catalysts for the Synthesis of Glucuronic Acid Esters under Microwave Irradiation. ChemSusChem, 2010, 3 (11), pp.1249-1252. ⟨10.1002/cssc.201000218⟩. ⟨hal-04315445⟩
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