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Article Dans Une Revue European Respiratory Journal Année : 2013

Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II

1 CESP - Centre de recherche en épidémiologie et santé des populations
2 Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Hospital del Mar Medical Research Institute (IMIM), Barcelona and CIBER Epidemiologıa y Salud Publica (CIBERESP), Barcelona, Spain
3 Inserm, U823, Centre for Research Albert Bonniot, Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble and Université Joseph Fourier, Grenoble, France
4 Institute for Occupational, Social and Environmental Medicine, Hospital of the Ludwig-Maximilian, University Munich, Munich, Germany
5 Uppsala University
6 Section of Occupational and Environmental Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
7 Unit of Occupational Medicine, University of Verona, Verona, Italy
8 Respiratory Dept, Galdakao Hospital, Galdakao, Spain
9 Unit of Epidemiology and Medical Statistics, Dept of Medicine and Public Health, University of Verona, Verona, Italy
10 Dept of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
11 Institute for Risk Assessment Sciences, Environmental Epidemiology Division, Utrecht University, Utrecht, The Netherlands
12 Dept of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA
13 Unibas - Université de Bâle = University of Basel = Basel Universität
14 Aarhus University [Aarhus]
15 UC San Francisco - University of California [San Francisco]
16 Centre for Research in Environmental Epidemiology (CREAL), Barcelona; Hospital del Mar Medical Research Institute (IMIM), Barcelona; CIBER Epidemiologı ́a y Salud Pu ́blica (CIBERESP), Barcelona, Spain; and National School of Public Health, Athens, Greece
17 IMIM-Hospital del Mar
18 Centre for Research in Environmental Epidemiology (CREAL), Barcelona; Hospital del Mar Medical Research Institute (IMIM), Barcelona; and CIBER Epidemiologıa y Salud Publica (CIBERESP), Barcelona, Spain
Dan Norback
  • Fonction : Auteur
J M Anto
  • Fonction : Auteur

Résumé

Occupational exposure is a well-recognised modifiable risk factor for asthma, but the relationship between occupational exposure and asthma control has not been studied. We aimed to study this association among working-age adults from the European Community Respiratory Health Survey (ECRHS). Data were available for 7077 participants (mean age 43 years, 45% never-smokers, 5867 without asthma and 1210 with current asthma). Associations between occupational exposure to specific asthmagens and asthma control status (33% with uncontrolled asthma, based on the Global Initiative for Asthma guidelines) were evaluated using logistic and multinomial regressions, adjusted for age, sex and smoking status, with study areas included as a random effect. Statistically significant positive associations were observed between uncontrolled adult-onset asthma and both past 12-month and 10-year exposure to any occupational asthmagens (OR (95% CI) 1.6 (1.0-2.40) and 1.7 (1.2-2.5), respectively); high (1.7 (1.0-2.8) and 1.9 (1.3-2.9), respectively) and low (1.6 (1.0-2.7) and 1.8 (1.2-2.7), respectively) molecular weight agents; and cleaning agents (2.0 (1.1-3.6) and 2.3 (1.4-3.6), respectively), with stronger associations for long-term exposures. These associations were mainly explained by the exacerbation domain of asthma control and no associations were observed between asthmagens and partly controlled asthma. These findings suggest that occupational exposure to asthmagens is associated with uncontrolled adult-onset asthma. Occupational risk factors should be quickly identified to prevent uncontrolled asthma.
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Dates et versions

hal-04315322 , version 1 (30-11-2023)

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Nicole Le Moual, A.-E. Carsin, Valérie Siroux, Katja Radon, Dan Norback, et al.. Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II. European Respiratory Journal, 2013, 43 (2), pp.374 - 386. ⟨10.1183/09031936.00034913⟩. ⟨hal-04315322⟩
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