<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04315018</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-17T03:56:10+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Sub-inhibitory gentamicin pollution induces gentamicin resistance gene integration in class 1 integrons in the environment</title>
            <author role="aut">
              <persName>
                <forename type="first">Concepcion</forename>
                <surname>Sanchez-Cid</surname>
              </persName>
              <email type="md5">6adf2913f5c4a2532d98bc8d6e292aa7</email>
              <email type="domain">ec-lyon.fr</email>
              <idno type="idhal" notation="numeric">1154617</idno>
              <idno type="halauthorid" notation="string">1493674-1154617</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6154-3955</idno>
              <affiliation ref="#struct-408955"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Timothy</forename>
                <surname>Ghaly</surname>
              </persName>
              <idno type="halauthorid">2974558-0</idno>
              <affiliation ref="#struct-539566"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michael</forename>
                <surname>Gillings</surname>
              </persName>
              <idno type="halauthorid">1258277-0</idno>
              <affiliation ref="#struct-539566"/>
              <affiliation ref="#struct-539566"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Timothy</forename>
                <surname>M. Vogel</surname>
              </persName>
              <email type="md5">bc7121af4e3c0d3d9bab82bf8ee13881</email>
              <email type="domain">univ-lyon1.fr</email>
              <idno type="idhal" notation="string">timothy-m-vogel</idno>
              <idno type="idhal" notation="numeric">174855</idno>
              <idno type="halauthorid" notation="string">6374-174855</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9542-3246</idno>
              <idno type="IDREF">https://www.idref.fr/068676611</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=DxrYIlcAAAAJ</idno>
              <idno type="VIAF">https://viaf.org/viaf/61693727</idno>
              <idno type="ISNI">http://isni.org/isni/0000000000470871</idno>
              <affiliation ref="#struct-1001885"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Sabine</forename>
                <surname>ROSSI</surname>
              </persName>
              <email type="md5">a5e8dbe8a7959c08b4b3ddfa9cc6bfa4</email>
              <email type="domain">inrae.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-01-10 11:20:06</date>
              <date type="whenModified">2026-03-18 03:22:17</date>
              <date type="whenReleased">2025-01-13 14:22:00</date>
              <date type="whenProduced">2023-05-27</date>
              <date type="whenEndEmbargoed">2025-01-10</date>
              <ref type="file" target="https://hal.science/hal-04315018v1/document">
                <date notBefore="2025-01-10"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-04315018v1/file/2023_Sanchez-Cid_Scientific_Rep.pdf" id="file-4879045-4241680">
                <date notBefore="2025-01-10"/>
              </ref>
              <ref type="externalLink" target="https://www.nature.com/articles/s41598-023-35074-y.pdf"/>
              <fs>
                <f name="inra_etatDocument_local" notation="string" n="VE">
                  <string>inra_etatDocument_local_VE</string>
                </f>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="642558">
                <persName>
                  <forename>Sabine</forename>
                  <surname>ROSSI</surname>
                </persName>
                <email type="md5">a5e8dbe8a7959c08b4b3ddfa9cc6bfa4</email>
                <email type="domain">inrae.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04315018</idno>
            <idno type="halUri">https://hal.science/hal-04315018</idno>
            <idno type="halBibtex">sanchezcid:hal-04315018</idno>
            <idno type="halRefHtml">&lt;i&gt;Scientific Reports&lt;/i&gt;, 2023, 13 (1), pp.8612. &lt;a target="_blank" href="https://dx.doi.org/10.1038/s41598-023-35074-y"&gt;&amp;#x27E8;10.1038/s41598-023-35074-y&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Scientific Reports, 2023, 13 (1), pp.8612. &amp;#x27E8;10.1038/s41598-023-35074-y&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-4879045-4241680"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="SDE">Sciences De l'Environnement</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="INSA-LYON">Institut National des Sciences Appliquées de Lyon</idno>
            <idno type="stamp" n="EC-LYON">Ecole Centrale de Lyon</idno>
            <idno type="stamp" n="AMPERE" corresp="UNIV-LYON1">Ampère</idno>
            <idno type="stamp" n="GIP-BE">GIP Bretagne Environnement</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="INSA-GROUPE">Groupe INSA</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="ECOMIC" corresp="UNIV-LYON1">LEM - Laboratoire d'Ecologie Microbienne</idno>
            <idno type="stamp" n="ECOMIC-EQUIPE8" corresp="ECOMIC">Equipe 8. Multi-résistance environnementale et efflux bactérien </idno>
            <idno type="stamp" n="BIOEENVIS">Fédération de Recherche Biodiversité, Eau, Environnement, Ville, Santé (FR BioEEnViS)</idno>
            <idno type="stamp" n="TEST4-HALCNRS">collection test</idno>
            <idno type="stamp" n="DPT_ECODIV">Ecologie et biodiversité</idno>
            <idno type="stamp" n="INEE-CNRS">Institut écologie et environnement du CNRS</idno>
            <idno type="stamp" n="BIOEENVIS-AMPERE" corresp="BIOEENVIS">BIOEENVIS-AMPERE</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Sub-inhibitory gentamicin pollution induces gentamicin resistance gene integration in class 1 integrons in the environment</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Concepcion</forename>
                    <surname>Sanchez-Cid</surname>
                  </persName>
                  <email type="md5">6adf2913f5c4a2532d98bc8d6e292aa7</email>
                  <email type="domain">ec-lyon.fr</email>
                  <idno type="idhal" notation="numeric">1154617</idno>
                  <idno type="halauthorid" notation="string">1493674-1154617</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6154-3955</idno>
                  <affiliation ref="#struct-408955"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Timothy</forename>
                    <surname>Ghaly</surname>
                  </persName>
                  <idno type="halauthorid">2974558-0</idno>
                  <affiliation ref="#struct-539566"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michael</forename>
                    <surname>Gillings</surname>
                  </persName>
                  <idno type="halauthorid">1258277-0</idno>
                  <affiliation ref="#struct-539566"/>
                  <affiliation ref="#struct-539566"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Timothy</forename>
                    <surname>M. Vogel</surname>
                  </persName>
                  <email type="md5">bc7121af4e3c0d3d9bab82bf8ee13881</email>
                  <email type="domain">univ-lyon1.fr</email>
                  <idno type="idhal" notation="string">timothy-m-vogel</idno>
                  <idno type="idhal" notation="numeric">174855</idno>
                  <idno type="halauthorid" notation="string">6374-174855</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9542-3246</idno>
                  <idno type="IDREF">https://www.idref.fr/068676611</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=DxrYIlcAAAAJ</idno>
                  <idno type="VIAF">https://viaf.org/viaf/61693727</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000000470871</idno>
                  <affiliation ref="#struct-1001885"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">89181</idno>
                <idno type="issn">2045-2322</idno>
                <idno type="eissn">2045-2322</idno>
                <title level="j">Scientific Reports</title>
                <imprint>
                  <publisher>Nature Publishing Group</publisher>
                  <biblScope unit="volume">13</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">8612</biblScope>
                  <date type="datePub">2023-05-27</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1038/s41598-023-35074-y</idno>
              <idno type="pubmed">37244902</idno>
              <idno type="wos">000997228700003</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sde">Environmental Sciences</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Antibiotics at sub-inhibitory concentrations are often found in the environment. Here they could impose selective pressure on bacteria, leading to the selection and dissemination of antibiotic resistance, despite being under the inhibitory threshold. The goal of this study was to evaluate the effects of sub-inhibitory concentrations of gentamicin on environmental class 1 integron cassettes in natural river microbial communities. Gentamicin at sub-inhibitory concentrations promoted the integration and selection of gentamicin resistance genes (GmRG) in class 1 integrons after only a one-day exposure. Therefore, sub-inhibitory concentrations of gentamicin induced integron rearrangements, increasing the mobilization potential of gentamicin resistance genes and potentially increasing their dissemination in the environment. This study demonstrates the effects of antibiotics at sub-inhibitory concentrations in the environment and supports concerns about antibiotics as emerging pollutants.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="department" xml:id="struct-408955" status="OLD">
          <orgName>Ampère, Département Bioingénierie</orgName>
          <orgName type="acronym">BioIng</orgName>
          <date type="start">2011-01-01</date>
          <date type="end">2025-12-31</date>
          <desc>
            <address>
              <addrLine>Ecole Centrale de Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ampere-lab.fr/spip.php?rubrique89</ref>
          </desc>
          <listRelation>
            <relation active="#struct-31070" type="direct"/>
            <relation active="#struct-126765" type="indirect"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-194495" type="indirect"/>
            <relation active="#struct-219748" type="indirect"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation name="UMR5005" active="#struct-441569" type="indirect"/>
            <relation name="USC1407" active="#struct-577435" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-539566" status="VALID">
          <idno type="ROR">https://ror.org/01sf06y89</idno>
          <orgName>Macquarie University [Sydney]</orgName>
          <desc>
            <address>
              <addrLine>Sydney, NSW, 2109, Australia</addrLine>
              <country key="AU"/>
            </address>
            <ref type="url">https://www.mq.edu.au/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1001885" status="VALID">
          <idno type="IdRef">151344167</idno>
          <idno type="ISNI">0000000403843951</idno>
          <idno type="RNSR">199511997S</idno>
          <idno type="ROR">https://ror.org/053vv7851</idno>
          <orgName>Laboratoire d'Ecologie Microbienne - UMR 5557</orgName>
          <orgName type="acronym">LEM</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>BAT GREGOR MENDEL (ex 741)-4 et 43 Bvd du 11 Novembre 1918 69622 VILLEURBANNE CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://ecomicro.univ-lyon1.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-300422" type="direct"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5557" active="#struct-441569" type="direct"/>
            <relation name="UMR1418" active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-31070" status="OLD">
          <idno type="IdRef">149693435</idno>
          <idno type="ISNI">0000000123052936</idno>
          <idno type="RNSR">199911701C</idno>
          <idno type="ROR">https://ror.org/04xbczw40</idno>
          <idno type="Wikidata">Q2374376</idno>
          <orgName>Ampère</orgName>
          <orgName type="acronym">AMPERE</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2025-12-31</date>
          <desc>
            <address>
              <addrLine>Ecole Centrale de Lyon, 36 Avenue Guy de Collongue, 69134 Ecully CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ampere-lab.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-126765" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-219748" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation name="UMR5005" active="#struct-441569" type="direct"/>
            <relation name="USC1407" active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-126765" status="VALID">
          <idno type="ROR">https://ror.org/05s6rge65</idno>
          <orgName>École Centrale de Lyon</orgName>
          <orgName type="acronym">ECL</orgName>
          <desc>
            <address>
              <addrLine>36 avenue Guy de Collongue - 69134 Ecully cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ec-lyon.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301088" status="VALID">
          <idno type="ROR">https://ror.org/01rk35k63</idno>
          <orgName>Université de Lyon</orgName>
          <desc>
            <address>
              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-194495" status="VALID">
          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <idno type="ROR">https://ror.org/029brtt94</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>
            <address>
              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-219748" status="VALID">
          <idno type="IdRef">052444724</idno>
          <idno type="ISNI">0000 0001 2292 0228</idno>
          <orgName>Institut National des Sciences Appliquées de Lyon</orgName>
          <orgName type="acronym">INSA Lyon</orgName>
          <date type="start">1957-03-18</date>
          <desc>
            <address>
              <addrLine>20 Avenue Albert Einstein, 69621 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.insa-lyon.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
            <relation active="#struct-301232" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301232" status="VALID">
          <idno type="IdRef">162105150</idno>
          <orgName>Institut National des Sciences Appliquées</orgName>
          <orgName type="acronym">INSA</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-577435" status="VALID">
          <idno type="ROR">https://ror.org/003vg9w96</idno>
          <orgName>Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement</orgName>
          <orgName type="acronym">INRAE</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300422" status="OLD">
          <orgName>Ecole Nationale Vétérinaire de Lyon</orgName>
          <orgName type="acronym">ENVL</orgName>
          <date type="end">2010</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>