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Article Dans Une Revue European Respiratory Journal Année : 2014

Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role?

1 Division of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht
2 Division of Population Health Sciences
3 Division of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht
4 Julius Center for Health Sciences and Primary Care, and Institute for Molecular Medicine, University Medical Center Utrecht, Utrecht
5 U946 - Variabilité Génétique et Maladies Humaines
6 IUH - Institut Universitaire d'Hématologie
7 CESP - Centre de recherche en épidémiologie et santé des populations
8 Centre for Research in Environmental Epidemiology (CREAL), Municipal Institute of Medical Research (IMIM-Hospital del Mar), and CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona
9 Dept of Occupational and Environmental Medicine, National Heart and Lung Institute, Imperial College, London
10 Unibas - Université de Bâle = University of Basel = Basel Universität
11 Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, and Small Area Health Statistics Unit, MRC-PHE Centre for Environment and Health, Imperial College, London
12 Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College, London
13 Commissariat a` l’Energie Atomique, Institut de Ge ́nomique, Centre National de Ge ́notypage (CNG), Evry, France, and McGill University, Montreal, QC, Canada
14 Aarhus University [Aarhus]
15 INSERM, U823, and Universite ́ Joseph Fourier, Grenoble
16 Institute for Work and Health, Lausanne
17 Centre for Research in Environmental Epidemiology (CREAL), CIBER Epidemiologia y Salud Pu ́blica (CIBERESP), and Universitat Pompeu Fabra (UPF), Barcelona
18 Centre for Research in Environmental Epidemiology (CREAL), Municipal Institute of Medical Research (IMIM-Hospital del Mar), and CIBER Epidemiologia y Salud Pu ́ blica (CIBERESP), Barcelona, Spain, and National School of Public Health, Athens, Greece
19 Fondation Jean-Dausset-CEPH, U946

Résumé

Recently, a locus centred on rs9273349 in the HLA-DQ region emerged from genome-wide association studies of adult-onset asthma. We aimed to further investigate the role of human leukocyte antigen (HLA) class II in adult-onset asthma and a possible interaction with occupational exposures. We imputed classical HLA-II alleles from 7579 single-nucleotide polymorphisms in 6025 subjects (1202 with adult-onset asthma) from European cohorts: ECRHS, SAPALDIA, EGEA and B58C, and from surveys of bakers and agricultural workers. Based on an asthma-specific job-exposure matrix, 2629 subjects had ever been exposed to high molecular weight (HMW) allergens. We explored associations between 23 common HLA-II alleles and adult-onset asthma, and tested for gene-environment interaction with occupational exposure to HMW allergens. Interaction was also tested for rs9273349. Marginal associations of classical HLA-II alleles and adult-onset asthma were not statistically significant. Interaction was detected between the DPB1*03:01 allele and exposure to HMW allergens (p50.009), in particular to latex (p50.01). In the unexposed group, the DPB1*03:01 allele was associated with adult-onset asthma (OR 0.67, 95%CI 0.53-0.86). HMW allergen exposures did not modify the association of rs9273349 with adult-onset asthma. Common classical HLA-II alleles were not marginally associated with adult-onset asthma. The association of latex exposure and adult-onset asthma may be modified by DPB1*03:01. @ERSpublications In an analysis involving .6000 European adults, classical HLA-II alleles were not associated with adult-onset asthma http://ow.ly/xTdFm
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Origine : Publication financée par une institution
Licence : CC BY - Paternité

Dates et versions

hal-04314709 , version 1 (29-11-2023)

Identifiants

Citer

Lidwien a M Smit, David P Strachan, Roel Vermeulen, Paul I W de Bakker, Florence Demenais, et al.. Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role?. European Respiratory Journal, 2014, 44 (5), pp.1234 - 1242. ⟨10.1183/09031936.00068014⟩. ⟨hal-04314709⟩
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