Pile foundations are usually subjected to cyclic loading which could possibly causes a significant degradation of the friction mobilised along the pile shaft. Most of the experimental studies devoted to analysing the behaviour of the pile-soil interfaces under cyclic loading tests are performed at a few hundred of cycles. However, a large number of cycles of the order of hundreds of thousands may cause a severe degradation of pile capacity. The present work aims to study the effect of cyclic loading parameters on the evolution of shaft friction of pile subjected to a large number of cycles. The experimental study is based on a physical modelling in a calibration chamber of axial cyclic loading of single pile jacked into sand under a large number of cycles, up to 105. It is found that cyclic amplitude, confining pressure and soil density have a significant effect on the evolution of skin friction along the pile shaft at a large number of cycles.