Comparative analysis of sperm DNA methylation supports evolutionary acquired epigenetic plasticity for organ speciation - Archive ouverte HAL
Article Dans Une Revue Epigenomics Année : 2022

Comparative analysis of sperm DNA methylation supports evolutionary acquired epigenetic plasticity for organ speciation

Lars Ingerslev
  • Fonction : Auteur
Ali Altıntaş
Leonidas Lundell
Ann Hansen
  • Fonction : Auteur
Lewin Small
Christopher Workman
  • Fonction : Auteur

Résumé

Aim: To perform a comparative epigenomic analysis of DNA methylation in spermatozoa from humans, mice, rats and mini-pigs. Materials & methods: Genome-wide DNA methylation analysis was used to compare the methylation profiles of orthologous CpG sites. Transcription profiles of early embryo development were analyzed to provide insight into the association between sperm methylation and gene expression programming. Results: We identified DNA methylation variation near genes related to the central nervous system and signal transduction. Gene expression dynamics at different time points of preimplantation stages were modestly associated with spermatozoal DNA methylation at the nearest promoters. Conclusion: Conserved genomic regions subject to epigenetic variation across different species were associated with specific organ functions, suggesting their potential contribution to organ speciation and long-term adaptation to the environment.

Dates et versions

hal-04311644 , version 1 (28-11-2023)

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Citer

Farideh Moharrek, Lars Ingerslev, Ali Altıntaş, Leonidas Lundell, Ann Hansen, et al.. Comparative analysis of sperm DNA methylation supports evolutionary acquired epigenetic plasticity for organ speciation. Epigenomics, 2022, 14 (21), pp.1305-1324. ⟨10.2217/epi-2022-0168⟩. ⟨hal-04311644⟩
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