A Mediterranean Diet-Based Metabolomic Score and Cognitive Decline in Older Adults: A Case-Control Analysis Nested within the Three-City Cohort Study - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Molecular Nutrition and Food Research Année : 2023

A Mediterranean Diet-Based Metabolomic Score and Cognitive Decline in Older Adults: A Case-Control Analysis Nested within the Three-City Cohort Study

Alba Tor-Roca
  • Fonction : Auteur
Alex Sánchez-Pla
  • Fonction : Auteur
Aniko Korosi
  • Fonction : Auteur
Mercè Pallàs
  • Fonction : Auteur
Paul J Lucassen
  • Fonction : Auteur
Pol Castellano-Escuder
  • Fonction : Auteur
Ludwig Aigner
  • Fonction : Auteur
Raúl González-Domínguez
  • Fonction : Auteur
Francisco Carmona
  • Fonction : Auteur
Esteban Vegas
  • Fonction : Auteur
Hyunah Lee
  • Fonction : Auteur
Sandrine Thuret
  • Fonction : Auteur
Cristina Andres-Lacueva
  • Fonction : Auteur
Cécilia Samieri
  • Fonction : Auteur
Mireia Urpi-Sarda
  • Fonction : Auteur

Résumé

Evidence on the Mediterranean diet (MD) and age-related cognitive decline (CD) is still inconclusive partly due to self-reported dietary assessment. The aim of the current study is to develop an MD- metabolomic score (MDMS) and investigate its association with CD in community-dwelling older adults. This study includes participants from the Three-City Study from the Bordeaux (n = 418) and Dijon (n = 422) cohorts who are free of dementia at baseline. Repeated measures of cognition over 12 years are collected. An MDMS is designed based on serum biomarkers related to MD key food groups and using a targeted metabolomics platform. Associations with CD are investigated through conditional logistic regression (matched on age, sex, and education level) in both sample sets. The MDMS is found to be inversely associated with CD (odds ratio [OR] [95% confidence interval (CI)] = 0.90 [0.80-1.00]; p = 0.048) in the Bordeaux (discovery) cohort. Results are comparable in the Dijon (validation) cohort, with a trend toward significance (OR [95% CI] = 0.91 [0.83-1.01]; p = 0.084). A greater adherence to the MD, here assessed by a serum MDMS, is associated with lower odds of CD in older adults.
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hal-04309990 , version 1 (27-11-2023)

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Alba Tor-Roca, Alex Sánchez-Pla, Aniko Korosi, Mercè Pallàs, Paul J Lucassen, et al.. A Mediterranean Diet-Based Metabolomic Score and Cognitive Decline in Older Adults: A Case-Control Analysis Nested within the Three-City Cohort Study. Molecular Nutrition and Food Research, 2023, pp.e2300271. ⟨10.1002/mnfr.202300271⟩. ⟨hal-04309990⟩
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