TAX1BP1 a novel player in antigen presentation - Archive ouverte HAL
Article Dans Une Revue Autophagy Année : 2022

TAX1BP1 a novel player in antigen presentation

Résumé

CD4$^+$ T lymphocytes play a major role in establishing and maintaining antiviral immunity. They are activated by anti- genic peptides derived from extracellular or newly synthesized (endogenous) proteins presented by the MHC-II molecules. Little is known about the mechanisms leading to endogenous MHC-II-restricted antigen presentation. We recently revealed a novel function of the macroautophagy/autophagy receptor (AR), TAX1BP1, in the presentation of endogenous viral antigens to CD4$^+$ T cells. In this punctum, we will focus on MHC-II-restricted endogenous antigen presentation and the involvement of TAX1BP1 in the biology of MHC-II molecules.
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Dates et versions

hal-04308605 , version 1 (27-11-2023)

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Gabriela Sarango, Bénédicte Manoury, Arnaud Moris. TAX1BP1 a novel player in antigen presentation. Autophagy, 2022, 19 (7), pp.2153-2155. ⟨10.1080/15548627.2022.2153570⟩. ⟨hal-04308605⟩
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