Functions of LKB1 in neural crest development: The story unfolds - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Developmental Dynamics Année : 2023

Functions of LKB1 in neural crest development: The story unfolds

Anthony Lucas
  • Fonction : Auteur
Marc Billaud
  • Fonction : Auteur
Sakina Torch
  • Fonction : Auteur
Marie Mével‐aliset
  • Fonction : Auteur
Jordan Allard
  • Fonction : Auteur

Résumé

Neural crest cells (NCCs) are highly motile, multipotent, embryonic cells that delaminate from the dorsal edges of the neural tube. NCCs follow stereotypical long-range migratory pathways to reach target organs during development, where they give rise to multiple derivatives. The identification of reservoirs of neural crest stem cells that persist to adulthood has recently aroused renewed interest in the biology of NCCs. In this context, several recent studies have demonstrated the essential role of the metabolic kinase LKB1 in NCC establishment. This review surveys how LKB1 governs the formation and maintenance of several neural crest derivatives, including facial bones, melanocytes, Schwann cells, and the enteric nervous system. We also detail the underlying molecular mechanisms that involve downstream effectors of LKB1, in particular the contribution of the AMPK-mTOR signaling pathway to both polarity and metabolic processes. Collectively, these recent discoveries open promising perspectives for new therapeutic applications for the treatment of neural crest disorders.
Fichier principal
Vignette du fichier
Thibert et al., 2023 Functions of LKB1 in neural crest development The story unfolds.pdf (2.29 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04306186 , version 1 (24-11-2023)

Identifiants

Citer

Chantal Thibert, Anthony Lucas, Marc Billaud, Sakina Torch, Marie Mével‐aliset, et al.. Functions of LKB1 in neural crest development: The story unfolds. Developmental Dynamics, 2023, 252 (8), pp.1077 - 1095. ⟨10.1002/dvdy.581⟩. ⟨hal-04306186⟩

Collections

UGA CNRS ANR
3 Consultations
8 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More