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Article Dans Une Revue Genome Biology Année : 2022

Pan-cancer surveys indicate cell cycle-related roles of primate-specific genes in tumors and embryonic cerebrum

Chenyu Ma
  • Fonction : Auteur
Chunyan Li
Daqi Yu
  • Fonction : Auteur
Yufei Zhang
Dan Zhang
Tianhan Su
Jianmin Wu
Yong E Zhang

Résumé

Background: Despite having been extensively studied, it remains largely unclear why humans bear a particularly high risk of cancer. The antagonistic pleiotropy hypothesis predicts that primate-specific genes (PSGs) tend to promote tumorigenesis, while the molecular atavism hypothesis predicts that PSGs involved in tumors may represent recently derived duplicates of unicellular genes. However, these predictions have not been tested.
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hal-04304197 , version 1 (24-11-2023)

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Chenyu Ma, Chunyan Li, Huijing Ma, Daqi Yu, Yufei Zhang, et al.. Pan-cancer surveys indicate cell cycle-related roles of primate-specific genes in tumors and embryonic cerebrum. Genome Biology, 2022, 23 (1), pp.251. ⟨10.1186/s13059-022-02821-9⟩. ⟨hal-04304197⟩
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