Insight into the relationship between forced vital capacity and transfer of the lungs for carbon monoxide in patients with idiopathic pulmonary fibrosis
Résumé
Background: Forced vital capacity (FVC) is routinely used to quantify the severity and identify the progression of idiopathic pulmonary fibrosis (IPF). Although less commonly used, lung transfer of carbon monoxide (TLCO) correlates better with the severity of IPF than does FVC.
Methods: Aiming at studying how FVC behaves in relation to TLCO, we analysed cross-sectional data from 430 IPF patients, of which 221 had at least 2 assessments (performed 2.4 § 1.9 years apart) available for longitudinal analyses. Thresholds for identifying "abnormal" FVC and TLCO values were the statistically-defined lower limits of normal (LLN). For patients with longitudinal data, mean annual absolute declines of FVC and TLCO were calculated.
Results: The correlation between FVC and TLCO (%predicted) was weak (R 2 =0.21). FVC was "abnormal" (i.e.,
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Soumis le : mardi 21 novembre 2023-17:43:59
Dernière modification le : mercredi 18 décembre 2024-09:47:08
Citer
Thibaud Soumagne, Sébastien Quétant, Alicia Guillien, Loïc Falque, David Hess, et al.. Insight into the relationship between forced vital capacity and transfer of the lungs for carbon monoxide in patients with idiopathic pulmonary fibrosis. Respiratory Medicine and Research, 2023, 84, pp.101042. ⟨10.1016/j.resmer.2023.101042⟩. ⟨hal-04298632⟩
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