Abstract The introductory article to this special issue on intermediality and comics focuses on exploring the richness of graphic narrative beyond the conventional understanding of comics as a multimodal medium that often combines text and images. Primarily using diverse examples of Spanish comics as its focus, this essay investigates intermedial relations between comics and music, adaptation and animation, as well as the extension of comics beyond physical and digital spaces. Drawing on existing research on intermediality more broadly and specific scholarly literature that examines comics as an intermedial cultural production or in relation to other media, the article argues that intermediality has been a consistent theme throughout the history of Iberian comics and key to new aesthetic and conceptual explorations in the medium.