Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing. - Archive ouverte HAL Access content directly
Journal Articles Alzheimer's & Dementia : the Journal of the Alzheimer's Association Year : 2023

Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing.

Ben Chun Pan Lam
  • Function : Author
Maria Fernanda Lima‐costa
  • Function : Author
Sergio Luis Blay
  • Function : Author
Erico Castro‐costa
  • Function : Author
Ki‐woong Kim
  • Function : Author
Steffi Riedel‐heller
  • Function : Author
Alexander Pabst
  • Function : Author
Suzana Shahar
  • Function : Author
Katya Numbers
  • Function : Author
Mary Ganguli
  • Function : Author
Tiffany F Hughes
  • Function : Author
Chung‐chou H Chang
  • Function : Author
Michael Crowe
  • Function : Author
Tze Pin Ng
  • Function : Author
Xinyi Gwee
  • Function : Author
Denise Qian Ling Chua
  • Function : Author
Joanna Rymaszewska
  • Function : Author
Karin Wolf‐ostermann
  • Function : Author
Anna‐karin Welmer
  • Function : Author
Jean Stafford
  • Function : Author
René Mélis
  • Function : Author
Myrra Vernooij‐dassen
  • Function : Author
Yun‐hee Jeon
  • Function : Author
Perminder S Sachdev
  • Function : Author
Henry Brodaty
  • Function : Author

Abstract

Introduction: Previous meta-analyses have linked social connections and mild cognitive impairment, dementia, and mortality. However, these used aggregate data from North America and Europe and examined a limited number of social connection markers. Methods: We used individual participant data (N = 39271, M age = 70.67 (40-102), 58.86% female, M education = 8.43 years, M follow-up = 3.22 years) from 13 longitudinal ageing studies. A two-stage meta-analysis of Cox regression models examined the association between social connection markers with our primary outcomes. Results: We found associations between good social connections structure and quality and lower risk of incident mild cognitive impairment (MCI); between social structure and function and lower risk of incident dementia and mortality. Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality. Discussion: Different aspects of social connections-structure, function, and qualityare associated with benefits for healthy aging internationally.
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Dates and versions

hal-04291836 , version 1 (17-11-2023)

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Gowsaly Mahalingam, Suraj Samtani, Ben Chun Pan Lam, Darren M Lipnicki, Maria Fernanda Lima‐costa, et al.. Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing.. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2023, 19, pp.5114 - 5128. ⟨10.1002/alz.13072⟩. ⟨hal-04291836⟩
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