Cross-species analysis of differential transcript usage in humans and chickens with fatty liver disease - Archive ouverte HAL Accéder directement au contenu
Pré-Publication, Document De Travail Année : 2023

Cross-species analysis of differential transcript usage in humans and chickens with fatty liver disease

Kaj Chokeshaiusaha
  • Fonction : Auteur
Thanida Sananmuang
  • Fonction : Auteur

Résumé

Background and Aim: Fatty liver disease is a common condition, characterized by excess fat accumulation in the liver. It can contribute to more severe liver-related health issues, making it a critical concern in avian and human medicine. Apart from modifying the gene expression of liver cells, the disease also alters the expression of specific transcript isoforms, which might serve as new biological markers for both species. This study aimed to identify cross species genes displaying differential expressions in their transcript isoforms in humans and chickens with fatty liver disease. Materials and Methods: We performed differential gene expression and differential transcript usage (DTU) analyses on messenger RNA datasets from the livers of both chickens and humans with fatty liver disease. Using appropriate cross-species gene identification methods, we reviewed the acquired candidate genes and their transcript isoforms to determine their potential role in fatty liver disease's pathogenesis. Results: We identified seven genes-ALG5, BRD7, DIABLO, RSU1, SFXN5, STIMATE, TJP3, and VDAC2-and their corresponding transcript isoforms as potential candidates (false discovery rate ≤0.05). Our findings showed that these genes most likely contribute to fatty
Fichier principal
Vignette du fichier
Kaj Chokeshaiusaha.pdf (840.59 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04289438 , version 1 (16-11-2023)
hal-04289438 , version 2 (27-05-2024)

Identifiants

  • HAL Id : hal-04289438 , version 1

Citer

Kaj Chokeshaiusaha, Thanida Sananmuang, Denis Puthier, Catherine N'Guyen. Cross-species analysis of differential transcript usage in humans and chickens with fatty liver disease. 2023. ⟨hal-04289438v1⟩
18 Consultations
16 Téléchargements

Partager

Gmail Mastodon Facebook X LinkedIn More