Occupational exposures to irritants and asthma in the CONSTANCES Cohort
Résumé
Knowledge of the impact chronic occupational exposures to irritants on asthma and its symptoms remains scarce. We studied associations between including disinfectants/cleaning products (DCP) solvents symptoms. Adults from French CONSTANCES population-based cohort completed questionnaires at baseline (2012-2021). Current was defined by lifetime with symptoms, attacks or medication in past 12 months, symptom score as sum 5 months. Occupational were assessed Asthma-specific Job-Exposure Matrix. used logistic negative binomial models stratified sex adjusted for age, smoking status, body mass index. Analyses included 115,540 adults (55% women, mean age 43 years, 10% current asthma, 40% ever exposed irritants). Modest observed exposure (odds ratio: 1.05, 95%CI 1.00-1.11), DCP (1.06, 1.00-1.12) 0.98-1.14) women. In men, only (1.10, 1.01-1.20) associated asthma. Ever increased both women (mean 1.08, 1.05-1.11) men (1.11, 1.07-1.15), especially (women: 1.09, 1.06-1.13, men: 1.21, 1.15-1.27) 1.14, 1.10-1.19, 1.10, 1.05-1.15). For score, smaller inverse exposures. Lifetime These should be carefully considered management.