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            <title xml:lang="en">Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair</title>
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            <funder>This work was supported by the National Natural Science Foundation of China (51803227, 22007090), the S&amp;T Innovation 2025 Major Special Program of Ningbo (2019B10063 and 2020Z091), the CAS President's International Fellowship for Visiting Scientists (2019VBA0016), and the open foundation of the state key laboratory of fluid power and mechatronic systems (GZKF-202119).</funder>
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              <date type="whenSubmitted">2025-07-09 08:47:59</date>
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            <idno type="halRefHtml">&lt;i&gt;Carbohydrate Polymers&lt;/i&gt;, 2023, Carbohydrate Polymers, 313, pp.120904. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.carbpol.2023.120904"&gt;&amp;#x27E8;10.1016/j.carbpol.2023.120904&amp;#x27E9;&lt;/a&gt;</idno>
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                <title xml:lang="en">Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair</title>
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                  <biblScope unit="volume">313</biblScope>
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                <term xml:lang="en">Wound healing</term>
                <term xml:lang="en">Injectable hydrogels</term>
                <term xml:lang="en">Dynamically covalent bonds</term>
                <term xml:lang="en">Bioactive polysaccharides</term>
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              <p>Delayed or chronic wound healing is one of severe clinical issues. Developing scaffold materials capable of supporting cells and inducing tissue regeneration remains a challenge. Here, a polysaccharide-based hydrogel is constructed for promoting full-thickness skin wound healing in mouse model. The engineering hydrogel consists of a dynamic crosslinking network formed by the Schiff base reaction between aldehyde-containing xyloglucan and methacrylated chitosan. Its reversible gel-sol-gel transition upon shearing force is highly beneficial to completely cover and fill irregular wound shape. The second covalent cross-linking network achieved by photo-initiated polymerization offers a feasible way to tune the mechanical property of hydrogel after injection, with an ideal mechanical adaptivity for clinical application. Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.</p>
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              <org type="consortium">Institute of Medical Sciences, The Second Hospital and Shandong University Center for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan 250033, China</org>
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