Article Dans Une Revue Carbohydrate Polymers Année : 2023

Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair

Hua Wei
  • Fonction : Auteur
Shengkai Yu
  • Fonction : Auteur
Yansheng Zhang
  • Fonction : Auteur
Hua Zhang
  • Fonction : Auteur
Yuxi Ma
  • Fonction : Auteur
Mengjia Xu
  • Fonction : Auteur
Peng An
  • Fonction : Auteur
Yang Zhou
  • Fonction : Auteur
Yen Wei
  • Fonction : Auteur
Jing Chen
  • Fonction : Auteur

Résumé

Delayed or chronic wound healing is one of severe clinical issues. Developing scaffold materials capable of supporting cells and inducing tissue regeneration remains a challenge. Here, a polysaccharide-based hydrogel is constructed for promoting full-thickness skin wound healing in mouse model. The engineering hydrogel consists of a dynamic crosslinking network formed by the Schiff base reaction between aldehyde-containing xyloglucan and methacrylated chitosan. Its reversible gel-sol-gel transition upon shearing force is highly beneficial to completely cover and fill irregular wound shape. The second covalent cross-linking network achieved by photo-initiated polymerization offers a feasible way to tune the mechanical property of hydrogel after injection, with an ideal mechanical adaptivity for clinical application. Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.

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hal-04284777 , version 1 (09-07-2025)

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Hua Wei, Shengkai Yu, Yansheng Zhang, Hua Zhang, Yuxi Ma, et al.. Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair. Carbohydrate Polymers, 2023, Carbohydrate Polymers, 313, pp.120904. ⟨10.1016/j.carbpol.2023.120904⟩. ⟨hal-04284777⟩
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