<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04284692</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-16T07:54:25+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells</title>
            <author role="aut">
              <persName>
                <forename type="first">Marjolaine</forename>
                <surname>Bauzone</surname>
              </persName>
              <idno type="halauthorid">2262865-0</idno>
              <affiliation ref="#struct-1004619"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mouloud</forename>
                <surname>Souidi</surname>
              </persName>
              <idno type="halauthorid">161121-0</idno>
              <affiliation ref="#struct-1004619"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anne-Frédérique</forename>
                <surname>Dessein</surname>
              </persName>
              <idno type="halauthorid">583606-0</idno>
              <affiliation ref="#struct-1004619"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Maxence</forename>
                <surname>Wisztorski</surname>
              </persName>
              <idno type="halauthorid">371446-0</idno>
              <affiliation ref="#struct-443423"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Audrey</forename>
                <surname>Vincent</surname>
              </persName>
              <idno type="idhal" notation="numeric">758855</idno>
              <idno type="halauthorid" notation="string">44255-758855</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0058-2058</idno>
              <affiliation ref="#struct-1004619"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Pascal</forename>
                <surname>Gimeno</surname>
              </persName>
              <email type="md5">2095441c39d241f33c6aea69a533cef3</email>
              <email type="domain">univ-lille.fr</email>
              <idno type="idhal" notation="string">jpg</idno>
              <idno type="idhal" notation="numeric">1349439</idno>
              <idno type="halauthorid" notation="string">2027083-1349439</idno>
              <affiliation ref="#struct-443423"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Didier</forename>
                <surname>Monté</surname>
              </persName>
              <idno type="halauthorid">12590-0</idno>
              <affiliation ref="#struct-1006336"/>
              <affiliation ref="#struct-523045"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Isabelle</forename>
                <surname>van Seuningen</surname>
              </persName>
              <email type="md5">a38fa3f8c915378b8a7e4e039e4321cc</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">isabelle-van-seuningen</idno>
              <idno type="idhal" notation="numeric">179339</idno>
              <idno type="halauthorid" notation="string">4292-179339</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/N-6176-2016</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3131-2694</idno>
              <idno type="IDREF">https://www.idref.fr/094282048</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/N-6176-2016</idno>
              <affiliation ref="#struct-1004619"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christian</forename>
                <surname>Gespach</surname>
              </persName>
              <idno type="halauthorid">1450631-0</idno>
              <affiliation ref="#struct-541912"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Guillemette</forename>
                <surname>Huet</surname>
              </persName>
              <email type="md5">cefc89c41147feee87c2779a83504119</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="numeric">1049648</idno>
              <idno type="halauthorid" notation="string">133461-1049648</idno>
              <affiliation ref="#struct-1004619"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Mouloud</forename>
                <surname>SOUIDI</surname>
              </persName>
              <email type="md5">c7d09b3c39ecc7bd78a6f32e7e54833f</email>
              <email type="domain">inserm.fr</email>
            </editor>
            <funder>This work was supported by Inserm, CNRS, grants from Fondation ARC, La Ligue Nationale Contre le Cancer (comité du Nord), SIRIC ONCOLille, Grant INCa-DGOS-Inserm 6041, and from "Contrat de Plan Etat Région" CPER Cancer 2007–2013. Marjolaine Bauzone received a predoctoral fellowship from the Ecole Doctorale Biologie-Santé.</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2023-11-14 13:47:04</date>
              <date type="whenModified">2026-03-06 13:46:01</date>
              <date type="whenReleased">2023-11-14 13:47:04</date>
              <date type="whenProduced">2021-04-02</date>
              <ref type="externalLink" target="https://aacrjournals.org/mcr/article-pdf/19/4/612/3102001/612.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1473555">
                <persName>
                  <forename>Mouloud</forename>
                  <surname>SOUIDI</surname>
                </persName>
                <email type="md5">c7d09b3c39ecc7bd78a6f32e7e54833f</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04284692</idno>
            <idno type="halUri">https://hal.science/hal-04284692</idno>
            <idno type="halBibtex">bauzone:hal-04284692</idno>
            <idno type="halRefHtml">&lt;i&gt;Molecular Cancer Research&lt;/i&gt;, 2021, 19 (4), pp.612-622. &lt;a target="_blank" href="https://dx.doi.org/10.1158/1541-7786.MCR-20-0462"&gt;&amp;#x27E8;10.1158/1541-7786.MCR-20-0462&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Molecular Cancer Research, 2021, 19 (4), pp.612-622. &amp;#x27E8;10.1158/1541-7786.MCR-20-0462&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="RIIP">Pasteur Network</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="RIIP_LILLE" corresp="RIIP">Institut Pasteur de Lille</idno>
            <idno type="stamp" n="U938" corresp="SORBONNE-UNIVERSITE">Centre de recherche Saint-Antoine - UMR S938</idno>
            <idno type="stamp" n="UNIV-LILLE">Université de Lille</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Santé de Sorbonne Université</idno>
            <idno type="stamp" n="CANTHER">Cancer heterogeneity, plasticity and resistance to therapies</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="RID_AGE">Facteurs de risques et déterminants moléculaires des maladies liées au vieillissement (U 1167)</idno>
            <idno type="stamp" n="SUPRA_-SVE6">SVE6 - Maladies humaines</idno>
            <idno type="stamp" n="PRISM-LILLE"> Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Marjolaine</forename>
                    <surname>Bauzone</surname>
                  </persName>
                  <idno type="halauthorid">2262865-0</idno>
                  <affiliation ref="#struct-1004619"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mouloud</forename>
                    <surname>Souidi</surname>
                  </persName>
                  <idno type="halauthorid">161121-0</idno>
                  <affiliation ref="#struct-1004619"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anne-Frédérique</forename>
                    <surname>Dessein</surname>
                  </persName>
                  <idno type="halauthorid">583606-0</idno>
                  <affiliation ref="#struct-1004619"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Maxence</forename>
                    <surname>Wisztorski</surname>
                  </persName>
                  <idno type="halauthorid">371446-0</idno>
                  <affiliation ref="#struct-443423"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Audrey</forename>
                    <surname>Vincent</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">758855</idno>
                  <idno type="halauthorid" notation="string">44255-758855</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0058-2058</idno>
                  <affiliation ref="#struct-1004619"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Pascal</forename>
                    <surname>Gimeno</surname>
                  </persName>
                  <email type="md5">2095441c39d241f33c6aea69a533cef3</email>
                  <email type="domain">univ-lille.fr</email>
                  <idno type="idhal" notation="string">jpg</idno>
                  <idno type="idhal" notation="numeric">1349439</idno>
                  <idno type="halauthorid" notation="string">2027083-1349439</idno>
                  <affiliation ref="#struct-443423"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Didier</forename>
                    <surname>Monté</surname>
                  </persName>
                  <idno type="halauthorid">12590-0</idno>
                  <affiliation ref="#struct-1006336"/>
                  <affiliation ref="#struct-523045"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Isabelle</forename>
                    <surname>van Seuningen</surname>
                  </persName>
                  <email type="md5">a38fa3f8c915378b8a7e4e039e4321cc</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">isabelle-van-seuningen</idno>
                  <idno type="idhal" notation="numeric">179339</idno>
                  <idno type="halauthorid" notation="string">4292-179339</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/N-6176-2016</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3131-2694</idno>
                  <idno type="IDREF">https://www.idref.fr/094282048</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/N-6176-2016</idno>
                  <affiliation ref="#struct-1004619"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christian</forename>
                    <surname>Gespach</surname>
                  </persName>
                  <idno type="halauthorid">1450631-0</idno>
                  <affiliation ref="#struct-541912"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Guillemette</forename>
                    <surname>Huet</surname>
                  </persName>
                  <email type="md5">cefc89c41147feee87c2779a83504119</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="numeric">1049648</idno>
                  <idno type="halauthorid" notation="string">133461-1049648</idno>
                  <affiliation ref="#struct-1004619"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">17164</idno>
                <idno type="issn">1541-7786</idno>
                <idno type="eissn">1557-3125</idno>
                <title level="j">Molecular Cancer Research</title>
                <imprint>
                  <publisher>American Association for Cancer Research</publisher>
                  <biblScope unit="volume">19</biblScope>
                  <biblScope unit="issue">4</biblScope>
                  <biblScope unit="pp">612-622</biblScope>
                  <date type="datePub">2021-04-02</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1158/1541-7786.MCR-20-0462</idno>
              <idno type="pubmed">33472949</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The mechanisms whereby the Hippo pathway effector YAP regulates cancer cell stemness, plasticity, and chemoresistance are not fully understood. We previously showed that in 5-fluorouracil (5-FU)–resistant colorectal cancer cells, the transcriptional coactivator YAP is differentially regulated at critical transitions connected with reversible quiescence/dormancy to promote metastasis. Here, we found that experimental YAP activation in 5-FU–sensitive and 5-FU–resistant HT29 colorectal cancer cells enhanced nuclear YAP localization and the transcript levels of the retinoic acid (RA) receptors RARα/γ and RAR target genes CYP26A1, ALDH1A3, and LGR5 through RA Response Elements (RARE). In these two cell models, constitutive YAP activation reinforced the expression of the stemness biomarkers and regulators ALDH1A3, LGR5, and OCT4. Conversely, YAP silencing, RAR/RXR inhibition by the pan-RAR antagonist BMS493, and vitamin A depletion downregulated stemness traits and self-renewal. Regarding the mechanisms engaged, proximity-dependent labeling, nuclear YAP pulldown coupled with mass spectrometry, and chromatin immunoprecipitation (ChIP)/re-ChIP experiments revealed: (i) the nuclear colocalization/interaction of YAP with RARγ and RXRs; and (ii) combined genomic co-occupancy of YAP, RARα/γ, and RXRα interactomes at proximal RAREs of LGR5 and ALDH1A3 promoters. Moreover, activation of the YAP/RAR-RXR cross-talk in colorectal cancer cells promoted RAR self-activation loops via vitamin A metabolism, RA, and active RAR ligands generated by ALDH1A3. Together, our data identify YAP as a bona fide RAR-RXR transcriptional coactivator that acts through RARE-activated stemness genes.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1004619" status="VALID">
          <idno type="IdRef">249814935</idno>
          <idno type="ISNI">0000000512425943</idno>
          <idno type="RNSR">202023551S</idno>
          <idno type="ROR">https://ror.org/05x9zmx47</idno>
          <idno type="Wikidata">Q116959474</idno>
          <orgName>Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277</orgName>
          <orgName type="acronym">CANTHER</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Laboratoire CANTHER, UMR 9020 CNRS-1277 Inserm -- Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers - Université de Lille - Bâtiment Cancer - Place de Verdun -59000 LILLE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.canther.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300166" type="direct"/>
            <relation active="#struct-301247" type="indirect"/>
            <relation name="U1277" active="#struct-303623" type="direct"/>
            <relation name="UMR9020" active="#struct-374570" type="direct"/>
            <relation name="UMR9020" active="#struct-425779" type="direct"/>
            <relation name="UMR9020" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-443423" status="VALID">
          <idno type="IdRef">161573533</idno>
          <idno type="RNSR">201119484K</idno>
          <idno type="ROR">https://ror.org/05dm3m993</idno>
          <idno type="Wikidata">Q30262542</idno>
          <orgName>Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192</orgName>
          <orgName type="acronym">PRISM</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lille - Campus Cité Scientifique - Faculté des Sciences et Technologies - Département de Biologie -- Avenue Paul Langevin - Bâtiment SN3 - 1er étage59655 Villeneuve d'Ascq Cedex France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.laboratoire-prism.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1192" active="#struct-303623" type="direct"/>
            <relation name="U1192" active="#struct-374570" type="direct"/>
            <relation name="U1192" active="#struct-425779" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1006336" status="OLD">
          <idno type="RNSR">202023515C</idno>
          <orgName>Biologie Structurale Intégrative</orgName>
          <orgName type="acronym">ERL 9002 - INSERM U1167 - BSI</orgName>
          <date type="start">2020-01-01</date>
          <date type="end">2025-12-31</date>
          <desc>
            <address>
              <addrLine>1 rue du Professeur Calmette 245, 59019 Lille Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://pasteur-lille.fr/centre-de-recherche/unites-de-recherche/facteurs-de-risque-et-determinants-moleculaires-des-maladies-liees-au-vieillissement/biologie-structurale-integrative/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300166" type="direct"/>
            <relation active="#struct-301247" type="indirect"/>
            <relation name="U1167" active="#struct-303623" type="direct"/>
            <relation active="#struct-374570" type="direct"/>
            <relation name="EMR9002 / ERL9002" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-523045" status="VALID">
          <idno type="IdRef">193516136</idno>
          <idno type="ISNI">0000000512376862</idno>
          <idno type="RNSR">200616418Z</idno>
          <idno type="ROR">https://ror.org/03rvrjk28</idno>
          <idno type="Wikidata">Q51781738</idno>
          <orgName>Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167</orgName>
          <orgName type="acronym">RID-AGE</orgName>
          <date type="start">2006-01-01</date>
          <desc>
            <address>
              <addrLine>Institut Pasteur de Lille - 1 rue du prof. Calmette - BP 245 - 59019 Lille Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://pasteur-lille.fr/centre-de-recherche/unites-de-recherche/facteurs-de-risque-et-determinants-moleculaires-des-maladies-liees-au-vieillissement/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300166" type="direct"/>
            <relation active="#struct-301247" type="indirect"/>
            <relation name="U1167" active="#struct-303623" type="direct"/>
            <relation name="U744" active="#struct-374570" type="direct"/>
            <relation name="U744" active="#struct-425779" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-541912" status="VALID">
          <idno type="RNSR">200918542V</idno>
          <orgName>Centre de Recherche Saint-Antoine</orgName>
          <orgName type="acronym">CRSA</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Kourilsky34 rue Crozatier75012 PARISSorbonne Université27 rue Chaligny75012 PARIS</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.crsa.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation name="U938" active="#struct-303623" type="direct"/>
            <relation name="UMRS_938" active="#struct-413221" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300166" status="VALID">
          <idno type="ROR">https://ror.org/05k9skc85</idno>
          <orgName>Institut Pasteur de Lille</orgName>
          <date type="start">1894</date>
          <desc>
            <address>
              <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.pasteur-lille.fr/accueil/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301247" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301247" status="VALID">
          <orgName>Pasteur Network (Réseau International des Instituts Pasteur)</orgName>
          <desc>
            <address>
              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://pasteur-network.org/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-374570" status="VALID">
          <idno type="IdRef">223446556</idno>
          <idno type="ISNI">0000 0001 2242 6780</idno>
          <idno type="ROR">https://ror.org/02kzqn938</idno>
          <idno type="Wikidata">Q3551621</idno>
          <orgName>Université de Lille</orgName>
          <desc>
            <address>
              <addrLine>EPE Université de Lille. -- 42 rue Paul Duez, 59000 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-425779" status="VALID">
          <idno type="IdRef">034424636</idno>
          <idno type="ISNI">0000000404718845</idno>
          <idno type="ROR">https://ror.org/02ppyfa04</idno>
          <idno type="Wikidata">Q2945741</idno>
          <orgName>Centre Hospitalier Régional Universitaire [CHU Lille]</orgName>
          <orgName type="acronym">CHRU Lille</orgName>
          <desc>
            <address>
              <addrLine>CHU/CHRU Lille - 2, avenue Oscar Lambret - 59037 Lille Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chru-lille.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>