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Article Dans Une Revue Drug Discovery Today Année : 2023

Harnessing G-quadruplex ligands for lung cancer treatment: A comprehensive overview

Résumé

Lung cancer (LC) remains a leading cause of mortality worldwide, and new therapeutic strategies are urgently needed. One such approach revolves around the utilization of four-stranded nucleic acid secondary structures, known as G-quadruplexes (G4), which are formed by G-rich sequences. G4 structures constitute enticing targets for therapeutic intervention. Ligands that bind selectively to G4 structures, present a promising strategy for regulating crucial cellular processes involved in the progression of LC, rendering them potent agents for lung cancer treatment. In this review, we offer a summary of the recent advancements in the development of ligands capable of targeting specific genes associated with the development and progression of lung cancer.
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Dates et versions

hal-04281006 , version 1 (12-11-2023)

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Joana Figueiredo, Mojgan Djavaheri-Mergny, Lucille Ferret, Jean-Louis Mergny, Carla Cruz. Harnessing G-quadruplex ligands for lung cancer treatment: A comprehensive overview. Drug Discovery Today, 2023, 28 (12), pp.103808. ⟨10.1016/j.drudis.2023.103808⟩. ⟨hal-04281006⟩
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