Single-cell analysis of megakaryopoiesis in peripheral CD34+ cells: insights into ETV6-related thrombocytopenia
Résumé
ETV6-related thrombocytopenia mechanisms remain poorly understood Megakaryopoiesis was studied by single-cell RNA sequencing and defects were confirmed ex-vivo ETV6 deficiency led to the development of aberrant haemopoietic cells as early as the MEP stage Upregulation of ribosome biogenesis were documented in patient megakaryocytes and platelets
Domaines
Sciences du Vivant [q-bio]| Origine | Fichiers produits par l'(les) auteur(s) |
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