Single-cell analysis of megakaryopoiesis in peripheral CD34+ cells: insights into ETV6-related thrombocytopenia - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Thrombosis and Haemostasis Année : 2023

Single-cell analysis of megakaryopoiesis in peripheral CD34+ cells: insights into ETV6-related thrombocytopenia

Céline Falaise
  • Fonction : Auteur
Marie Loosveld
  • Fonction : Auteur
Delphine Potier

Résumé

 ETV6-related thrombocytopenia mechanisms remain poorly understood  Megakaryopoiesis was studied by single-cell RNA sequencing and defects were confirmed ex-vivo  ETV6 deficiency led to the development of aberrant haemopoietic cells as early as the MEP stage  Upregulation of ribosome biogenesis were documented in patient megakaryocytes and platelets
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Dates et versions

hal-04275159 , version 1 (08-11-2023)

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Timothée Bigot, Elisa Gabinaud, Laurent Hannouche, Véronique Sbarra, Elisa Andersen, et al.. Single-cell analysis of megakaryopoiesis in peripheral CD34+ cells: insights into ETV6-related thrombocytopenia. Journal of Thrombosis and Haemostasis, 2023, 21 (9), pp.2528-2544. ⟨10.1016/j.jtha.2023.04.007⟩. ⟨hal-04275159⟩
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