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Journal Articles Orphanet Journal of Rare Diseases Year : 2023

French guidelines for the etiological workup of eosinophilia and the management of hypereosinophilic syndromes

Julien Rohmer
  • Function : Author
Nicolas Etienne
  • Function : Author
Wadih Abou Chahla
  • Function : Author
Antoine Baudet
  • Function : Author
Aurélie Chan Hew Wai
  • Function : Author
Irena Clisson Rusek
  • Function : Author
Fanny Delahousse
  • Function : Author
Stanislas Faguer
  • Function : Author
Florent Huang
  • Function : Author
Thierry Leblanc
  • Function : Author
Thierry Martin
  • Function : Author
Antoine Néel
  • Function : Author
Luc Paris
  • Function : Author
Arnaud Petit
  • Function : Author
Julien Rossignol
  • Function : Author
Nicolas Schleinitz
  • Function : Author
Juliette Soret-Dulphy
  • Function : Author
Benjamin Terrier
  • Function : Author
Jean-François Viallard
  • Function : Author

Abstract

Abstract Eosinophilic-related clinical manifestations are protean and the underlying conditions underpinning eosinophilia are highly diverse. The etiological workup of unexplained eosinophilia/hypereosinophilia can be challenging, and can lead sometimes to extensive, inappropriate, costly and/or invasive investigations. To date, guidelines for the etiological workup and management of eosinophilia are mainly issued by hematologists, and thus mostly cover the scope of clonal hypereosinophilic syndromes (HES). Here, thanks to an extensive literature review, and thanks to the joint work of a large panel of experts involving physicians from both adult and pediatric medicine and from various subspecialties (as well as a representative of a patients’ association representative), we provide recommendations for both the step-by step diagnostic workup of eosinophilia (whether unexplained or within specific contexts) as well as the management and follow-up of the full spectrum of eosinophilic disorders (including clonal, reactive, lymphocytic and idiopathic HES, as well as single-organ diseases). Didactic prescription summaries intended to facilitate the prescription of eosinophil-targeted drugs are also provided, as are practical diagnostic and therapeutic algorithms. Lastly, this set of recommendations also includes a summary intended for general practitioners, as well as an overview of the therapeutic patient education program set up by the French reference center for HES. Further updates will be mandatory as new validated information emerges.

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hal-04274899 , version 1 (08-11-2023)

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Matthieu Groh, Julien Rohmer, Nicolas Etienne, Wadih Abou Chahla, Antoine Baudet, et al.. French guidelines for the etiological workup of eosinophilia and the management of hypereosinophilic syndromes. Orphanet Journal of Rare Diseases, 2023, 18 (1), pp.100. ⟨10.1186/s13023-023-02696-4⟩. ⟨hal-04274899⟩
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