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Article Dans Une Revue Orphanet Journal of Rare Diseases Année : 2023

French guidelines for the etiological workup of eosinophilia and the management of hypereosinophilic syndromes

Julien Rohmer
  • Fonction : Auteur
Nicolas Etienne
  • Fonction : Auteur
Wadih Abou Chahla
  • Fonction : Auteur
Antoine Baudet
  • Fonction : Auteur
Aurélie Chan Hew Wai
  • Fonction : Auteur
Irena Clisson Rusek
  • Fonction : Auteur
Fanny Delahousse
  • Fonction : Auteur
Stanislas Faguer
  • Fonction : Auteur
Florent Huang
  • Fonction : Auteur
Thierry Leblanc
  • Fonction : Auteur
Thierry Martin
  • Fonction : Auteur
Antoine Néel
  • Fonction : Auteur
Luc Paris
  • Fonction : Auteur
Arnaud Petit
  • Fonction : Auteur
Julien Rossignol
  • Fonction : Auteur
Nicolas Schleinitz
  • Fonction : Auteur
Juliette Soret-Dulphy
  • Fonction : Auteur
Benjamin Terrier
  • Fonction : Auteur
Jean-François Viallard
  • Fonction : Auteur

Résumé

Abstract Eosinophilic-related clinical manifestations are protean and the underlying conditions underpinning eosinophilia are highly diverse. The etiological workup of unexplained eosinophilia/hypereosinophilia can be challenging, and can lead sometimes to extensive, inappropriate, costly and/or invasive investigations. To date, guidelines for the etiological workup and management of eosinophilia are mainly issued by hematologists, and thus mostly cover the scope of clonal hypereosinophilic syndromes (HES). Here, thanks to an extensive literature review, and thanks to the joint work of a large panel of experts involving physicians from both adult and pediatric medicine and from various subspecialties (as well as a representative of a patients’ association representative), we provide recommendations for both the step-by step diagnostic workup of eosinophilia (whether unexplained or within specific contexts) as well as the management and follow-up of the full spectrum of eosinophilic disorders (including clonal, reactive, lymphocytic and idiopathic HES, as well as single-organ diseases). Didactic prescription summaries intended to facilitate the prescription of eosinophil-targeted drugs are also provided, as are practical diagnostic and therapeutic algorithms. Lastly, this set of recommendations also includes a summary intended for general practitioners, as well as an overview of the therapeutic patient education program set up by the French reference center for HES. Further updates will be mandatory as new validated information emerges.

Dates et versions

hal-04274899 , version 1 (08-11-2023)

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Matthieu Groh, Julien Rohmer, Nicolas Etienne, Wadih Abou Chahla, Antoine Baudet, et al.. French guidelines for the etiological workup of eosinophilia and the management of hypereosinophilic syndromes. Orphanet Journal of Rare Diseases, 2023, 18 (1), pp.100. ⟨10.1186/s13023-023-02696-4⟩. ⟨hal-04274899⟩
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